INCB054329
CAS No. 1628607-64-6
INCB054329 ( INCB 054329 )
产品货号. M12432 CAS No. 1628607-64-6
INCB054329 is a novel potent, orally bioactive BET inhibitor that inhibits binding of BRD2, BRD3 and BRD4 to an acetylated histone H4 peptide with low nanomolar potency.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥1256 | 有现货 |
|
10MG | ¥2001 | 有现货 |
|
25MG | ¥4026 | 有现货 |
|
50MG | ¥5856 | 有现货 |
|
100MG | ¥7995 | 有现货 |
|
200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称INCB054329
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述INCB054329 is a novel potent, orally bioactive BET inhibitor that inhibits binding of BRD2, BRD3 and BRD4 to an acetylated histone H4 peptide with low nanomolar potency.
-
产品描述INCB054329 is a novel potent, orally bioactive BET inhibitor that inhibits binding of BRD2, BRD3 and BRD4 to an acetylated histone H4 peptide with low nanomolar potency; inhibits expression of c-MYC and induced HEXIM1 in myeloma cell lines; inhibits growth of the majority of myeloma, AML, and lymphoma cell lines with IC50<100 nM; induces G1 arrest and cell apoptosis consistent with increased expression of pro-apoptotic regulators; inhibits tumor growth in vivo.
-
同义词INCB 054329
-
通路Chromatin/Epigenetic
-
靶点Bromodomain
-
受体Bromodomain
-
研究领域——
-
适应症——
化学信息
-
CAS Number1628607-64-6
-
分子量348.36
-
分子式C19H16N4O3
-
纯度>98% (HPLC)
-
溶解度DMSO : ≥ 100 mg/mL 287.06 mM
-
SMILESO=C1N2[C@H](COC3=C2C(N1)=CC=C3C4=C(ON=C4C)C)C5=CC=CC=N5
-
化学全称(S)-6-(3,5-dimethylisoxazol-4-yl)-3-(pyridin-2-yl)-3,4-dihydro-5-oxa-1,2a-diazaacenaphthylen-2(1H)-one
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Phillip CC Liu, et al. DOI: 10.1158/1538-7445.AM2015-3523 Published August 2015
2. Pérez-Salvia M, et al. Epigenetics. 2017 May 4;12(5):323-339.
2. Pérez-Salvia M, et al. Epigenetics. 2017 May 4;12(5):323-339.
产品手册
关联产品
-
TPOP146
A potent and selective CBP/p300 bromodomain inhibitor with Kd of 134 nM for CBP bromodomain.
-
CPI703
A potent, selective, cell-active CBP/EP300 bromodomain inhibitor with IC50 of 0.47 uM for CBP.
-
GNE-371
GNE-371 (GNE371) is a highly potent and selective chemical probe for the second bromodomain of TAF1 (TAF1(2)) with IC50/Kd of 10/1 nM.