GNE-371 ( GNE371;GNE 371 )

产品货号. M13017 CAS No. 1926986-36-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

GNE-371
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

GNE-371 (GNE371) is a highly potent and selective chemical probe for the second bromodomain of TAF1 (TAF1(2)) with IC50/Kd of 10/1 nM.
产品描述

GNE-371 (GNE371) is a highly potent and selective chemical probe for the second bromodomain of TAF1 (TAF1(2)) with IC50/Kd of 10/1 nM, without significant activity against other bromodomain-family members; GNE-371 (GNE371) is also active in a cellular-TAF1(2) target-engagement assay (IC50=38 nM) and exhibits antiproliferative synergy with the BET inhibitor JQ1, suggesting engagement of endogenous TAF1 by GNE-371.
同义词

GNE371;GNE 371
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

Bromodomain
研究领域

——
适应症

——

CAS Number

1926986-36-8
分子量

431.50
分子式

C24H25N5O3
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C1C(NC=C2)=C2C(C3=C4N=CN(C)C4=CC(C(N5CCOCC5)=O)=C3)=CN1CCC=C
化学全称

6-But-3-enyl-4-[1-methyl-6-(morpholine-4-carbonyl)-benzimidazol-4-yl]-1H-pyrrolo[2,3-c]pyridin-7-one

1. Wang S, et al. J Med Chem. 2018 Oct 25;61(20):9301-9315.

计算器

产品手册

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