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GNE-371
CAS No. 1926986-36-8
GNE-371 ( GNE371 | GNE 371 )
产品货号. M13017 CAS No. 1926986-36-8
GNE-371 (GNE371) 是一种针对 TAF1 (TAF1(2)) 第二溴结构域的高效选择性化学探针，IC50/Kd 为 10/1 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥3224 | 有现货 |
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| 50MG | ￥16119 | 有现货 |
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| 100MG | ￥25515 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称GNE-371
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述GNE-371 (GNE371) 是一种针对 TAF1 (TAF1(2)) 第二溴结构域的高效选择性化学探针，IC50/Kd 为 10/1 nM。
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产品描述GNE-371 (GNE371) is a highly potent and selective chemical probe for the second bromodomain of TAF1 (TAF1(2)) with IC50/Kd of 10/1 nM, without significant activity against other bromodomain-family members; GNE-371 (GNE371) is also active in a cellular-TAF1(2) target-engagement assay (IC50=38 nM) and exhibits antiproliferative synergy with the BET inhibitor JQ1, suggesting engagement of endogenous TAF1 by GNE-371.
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体外实验GNE-371 (compound 27) binds TAF1(2) with an IC50 of 10 nM while maintaining excellent selectivity over other bromodomain-family members. GNE-371 is also active in a cellular-TAF1(2) target-engagement assay (IC50=38 nM) and exhibits anti-proliferative synergy with the BET inhibitor JQ1, suggesting engagement of endogenous TAF1 by GNE-371 and further supporting the use of GNE-371 in mechanistic and target-validation studies.
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体内实验——
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同义词GNE371 | GNE 371
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通路Chromatin/Epigenetic
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靶点Bromodomain
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受体Bromodomain
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研究领域——
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适应症——
化学信息
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CAS Number1926986-36-8
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分子量431.496
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分子式C24H25N5O3
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 50 mg/mL (115.88 mM)
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SMILESO=C1C(NC=C2)=C2C(C3=C4N=CN(C)C4=CC(C(N5CCOCC5)=O)=C3)=CN1CCC=C
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化学全称6-But-3-enyl-4-[1-methyl-6-(morpholine-4-carbonyl)-benzimidazol-4-yl]-1H-pyrrolo[2,3-c]pyridin-7-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Wang S, et al. J Med Chem. 2018 Oct 25;61(20):9301-9315.
