TPOP146 ( TPOP-146;TPOP 146 )

产品货号. M13144 CAS No. 2018300-62-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

TPOP146
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A potent and selective CBP/p300 bromodomain inhibitor with Kd of 134 nM for CBP bromodomain.
产品描述

A potent and selective CBP/p300 bromodomain inhibitor with Kd of 134 nM for CBP bromodomain, displays excellent selectivity over other bromodomains (>30-fold over BRD4 (1)); targets the CBP bromodomain in the nucleus and is capable of competing with acetyl-lysine mediated interactions of the CBP bromodomain in cellular environments.
同义词

TPOP-146;TPOP 146
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

Bromodomain
研究领域

——
适应症

——

CAS Number

2018300-62-2
分子量

481.58
分子式

C27H35N3O5
纯度

>98% (HPLC)
溶解度

DMSO
SMILES

COC1=CC(C2=CC(C(N[C@H]3CCCN(C)C3)=O)=C(OCCN(C(CC)=O)C4)C4=C2)=CC(OC)=C1
化学全称

1,4-Benzoxazepine-9-carboxamide, 7-(3,5-dimethoxyphenyl)-2,3,4,5-tetrahydro-N-[(3S)-1-methyl-3-piperidinyl]-4-(1-oxopropyl)-

1. Popp TA, et al. J Med Chem. 2016 Oct 13;59(19):8889-8912.

计算器

产品手册

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