CPI703 ( CPI-703;CPI 703 )

产品货号. M12987 CAS No. 1904649-00-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

CPI703
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A potent, selective, cell-active CBP/EP300 bromodomain inhibitor with IC50 of 0.47 uM for CBP.
产品描述

A potent, selective, cell-active CBP/EP300 bromodomain inhibitor with IC50 of 0.47 uM for CBP; displays little to no (>200-fold selectivity) activity for BRD9, BRD4, BRPF1, TRIM24, BRG1 and BACF (IC50>10 uM); inhibits CBP bromodomain binding in a dose-dependent manner with cellular EC50 of 2.1 uM, reduces Treg differentiation and exhibits FOXP3 inhibition with IC50 of 1.5 uM, significantly affects TH17 differentiation, suppresses TH17 cytokines, IL-17A, IL-17F, and IL-21 with no effect on TNFα production or cell viability.
同义词

CPI-703;CPI 703
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

Bromodomain
研究领域

——
适应症

——

CAS Number

1904649-00-8
分子量

298.39
分子式

C17H22N4O
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C1C[C@@H](C)NC2=C(C3=CN(C(C)(C)C)N=C3)C=CC=C2N1
化学全称

(R)-6-(1-(tert-butyl)-1H-pyrazol-4-yl)-4-methyl-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one

1. Ghosh S, et al. J Biol Chem. 2016 Jun 17;291(25):13014-27.

计算器

产品手册

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