RVX2135 ( RVX 2135 )

产品货号. M11020 CAS No. 1253733-17-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

RVX2135
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

RVX2135 is a novel potent and orally bioavailable inhibitor of Brd2, Brd3, Brd4, and BrdT.
产品描述

RVX2135 is a novel potent and orally bioavailable inhibitor of Brd2, Brd3, Brd4, and BrdT with IC50 of 1.31, 0.58, 0.44, and 1.58 uM, respectively; blocks proliferation of Myc-induced mouse lymphoma cells and induces Caspase-dependent apoptosis; exhibits broad transcriptional effects in Myc-transgenic lymphoma cells affecting many transcription factor networks.
同义词

RVX 2135
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

Bromodomain
研究领域

——
适应症

——

CAS Number

1253733-17-3
分子量

411.50
分子式

C23H29N3O4
纯度

>98% (HPLC)
溶解度

——
SMILES

CC1=C(OCCNC(C)C)C(C)=CC(C2=NC3=CC(OC)=CC(OC)=C3C(N2)=O)=C1
化学全称

2-(4-(2-(isopropylamino)ethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one

1. Pérez-Salvia M, et al. Epigenetics. 2017 May 4;12(5):323-339.
2. Bhadury J, et al. Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):E2721-30.

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产品手册

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