BI-7273 ( BI7273;BI 7273 )

产品货号. M12926 CAS No. 1883429-21-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

BI-7273
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A potent, selective and cell-permeable BRD9 bromodomain inhibitor with IC50 of 19 nM in Alpha assay.
产品描述

A potent, selective and cell-permeable BRD9 bromodomain inhibitor with IC50 of 19 nM in Alpha assay; displays >5-fold selectiveity over BRD7, and >5,000-fold over BRD4-BD1, BRD4-BD2, and BRD2-BD1; blocks EOL-1 cell proliferation with EC50 of 1.4 uM, and displays antitumor activity in an AML xenograft model.
同义词

BI7273;BI 7273
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

BRD7;BRD9
研究领域

Cancer
适应症

——

CAS Number

1883429-21-7
分子量

353.41
分子式

C20H23N3O3
纯度

>98% (HPLC)
溶解度

DMSO: 10 mg/mL
SMILES

O=C1N(C)C=C(C2=CC(OC)=C(CN(C)C)C(OC)=C2)C3=CC=NC=C13
化学全称

2,7-Naphthyridin-1(2H)-one, 4-[4-[(dimethylamino)methyl]-3,5-dimethoxyphenyl]-2-methyl-

1. Martin LJ, et al. J Med Chem. 2016 May 26;59(10):4462-75.

计算器

产品手册

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