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GSK-923295
CAS No. 1088965-37-0
GSK-923295 ( GSK 923295;GSK923295 )
产品货号. M10340 CAS No. 1088965-37-0
The first potent, allosteric inhibitor of CENP-E kinesin motor ATPase activity with Ki of 3.2 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥518 | 有现货 |
|
| 5MG | ￥794 | 有现货 |
|
| 10MG | ￥1434 | 有现货 |
|
| 25MG | ￥2827 | 有现货 |
|
| 50MG | ￥4350 | 有现货 |
|
| 100MG | ￥6278 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称GSK-923295
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述The first potent, allosteric inhibitor of CENP-E kinesin motor ATPase activity with Ki of 3.2 nM.
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产品描述The first potent, allosteric inhibitor of CENP-E kinesin motor ATPase activity with Ki of 3.2 nM; shows excellent selectivity against a panel of mitotic human kinesins; exhibits inhibition of cell proliferation in a broad panel of human cancer cell lines and induces mitotic arrest leading to apoptosis and cell death (SKOV-3 IC50=22 nM; Colo205 IC50=22 nM); induces tumor regressions in vivo.Solid Tumors Phase 1 Clinical
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同义词GSK 923295;GSK923295
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通路Cytoskeleton/Cell Adhesion Molecules
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靶点Kinesin
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受体CENP-E
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研究领域Cancer
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适应症Solid Tumors
化学信息
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CAS Number1088965-37-0
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分子量592.13
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分子式C32H38ClN5O4
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESO=C(N[C@@H](CC1=CC=C(C2=CN3C=CC=C([C@@H](O)C)C3=N2)C=C1)CNC(CN(C)C)=O)C4=CC=C(OC(C)C)C(Cl)=C4
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化学全称Benzamide, 3-chloro-N-[(1S)-2-[[2-(dimethylamino)acetyl]amino]-1-[[4-[8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl]phenyl]methyl]ethyl]-4-(1-methylethoxy)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Wood KW, et al. Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5839-44.
2. Qian X, et al. ACS Med Chem Lett. 2010 Jan 19;1(1):30-4.
3. Balamuth NJ, et al. Cancer Res. 2010 Apr 1;70(7):2749-58.
2. Qian X, et al. ACS Med Chem Lett. 2010 Jan 19;1(1):30-4.
3. Balamuth NJ, et al. Cancer Res. 2010 Apr 1;70(7):2749-58.
产品手册
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