GSK-2878175 ( GSK2878175;GSK8175;GSK-175;GSK-175A )

产品货号. M11780 CAS No. 1423007-82-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

GSK-2878175
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

GSK-2878175 (GSK-175, GSK-175A) is a potent, pan-genotypic, second generation HCV NS5B polymerase inhibitor with EC50 of 0.4-9.7 nM.
产品描述

GSK-2878175 (GSK-175, GSK-175A) is a potent, pan-genotypic, second generation HCV NS5B polymerase inhibitor with EC50 of 0.4-9.7 nM;exhibited low in vivo clearance across preclinical species and broad-spectrum activity against HCV replicons, displayed a 60-63 h half-life and a robust decrease in viral RNA levels in HCV infected patients relative to GSK5852.HCV Infection Phase 2 Clinical
同义词

GSK2878175;GSK8175;GSK-175;GSK-175A
通路

Microbiology/Virology
靶点

HCV
受体

HCV
研究领域

Infection
适应症

HCV Infection

CAS Number

1423007-82-2
分子量

568.81
分子式

C27H23BClFN2O6S
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C(C1=C(C2=CC=C(F)C=C2)OC3=CC(N(C4=CC(Cl)=C5C(COB5O)=C4)S(=O)(C)=O)=C(C6CC6)C=C13)NC
化学全称

6-[N-(7-chloro-1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)methanesulfonamido]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

1. Gardner SD, et al. J Viral Hepat. 2018 Jan;25(1):19-27.
2.Chong PY, et al. J Med Chem. 2019 Feb 14. doi: 10.1021/acs.jmedchem.8b01719.

计算器

产品手册

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