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DHODH-IN-8

CAS No. 1148126-03-7

DHODH-IN-8 ( —— )

产品货号. M26161 CAS No. 1148126-03-7

DHODH-IN-8 has antimalarial activity. DHODH-IN-8 is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) .

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥2373 有现货
5MG ¥3629 有现货
10MG ¥5330 有现货
25MG ¥7995 有现货
50MG ¥11178 有现货
100MG ¥15309 有现货
500MG ¥30618 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    DHODH-IN-8
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    DHODH-IN-8 has antimalarial activity. DHODH-IN-8 is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) .
  • 产品描述
    DHODH-IN-8 has antimalarial activity. DHODH-IN-8 is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC50 of 0.13 μM and 47.4 μM, and Kis of 0.016 μM and 5.6 μM, respectively.(In Vitro):Dihydroorotic acid dehydrogenase (DHODH) is an attractive chemotherapeutic target among various pathogens, such as Plasmodium falciparum and Helicobacter pylori, and is used to treat human diseases. DHODH catalyzes the conversion of dihydroorotate (DHO) to orotate by using the FMN cofactor in the only redox reaction present in the pyrimidine biosynthesis pathway. Human DHODH (HsDHODH)a and Plasmodium falciparum DHODH (PfDHODH) are both DHODHs using respiratory quinones as terminal electron acceptors.
  • 同义词
    ——
  • 通路
    Metabolic Enzyme/Protease
  • 靶点
    Dehydrogenase
  • 受体
    ——
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    1148126-03-7
  • 分子量
    312.8
  • 分子式
    C17H13ClN2O2
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    C\C(O)=C(/C#N)C(=O)Nc1ccc(cc1)-c1ccccc1Cl
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.I A Butovich, et al. Oxidation of linoleyl alcohol by potato tuber lipoxygenase: kinetics and positional, stereo, and geometrical (cis, trans) specificity of the reaction. Arch Biochem Biophys. 2000 Jun 1;378(1):65-77.
产品手册
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