Qc1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Qc1 是苏氨酸脱氢酶 (TDH) 抑制剂，可用于代谢疾病的研究。

Qc1 is an inhibitor of threonine dehydrogenase (TDH) inhibitor and can be used in studies about metabolic diseases.(In Vitro):Qc1 prevents threonine dehydrogenase from catabolizing threonine into acetyl-CoA and glycine and blocks the charging of tetrahydrofolate(THF). In ES cells, Qc1 (10 μM) increases autophagic activity.

Qc1 (10 μM; 2~24 hours; ES cells) shows that a substantial fraction of the total LC3 protein is in the LC3-I (cytoplasmic) form. After 16 h of TDH inhibition, most LC3 is converted to the LC3-II (lipid-modified) form, indicative of increased autophagic activity.. Qc1 blocks the charging of tetrahydrofolate. Qc1 prevents threonine dehydrogenase from catabolizing threonine into acetyl-CoA and glycine.

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Qc 1

Metabolic Enzyme/Protease

Dehydrogenase

PAR-1|Apoptosis

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403718-45-6

455.45

C23H16F3N3O2S

>98% (HPLC)

In Vitro:?DMSO : 62.5 mg/mL (137.23 mM)

FC(F)(F)c1cccc(c1)N1C(=S)N=C2C=C(C=C[C@@H]2C1=O)C(=O)NCc1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years