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BHPI

CAS No. 56632-39-4

BHPI ( BHPI; )

产品货号. M15059 CAS No. 56632-39-4

BHPI is a potent, noncompetitive small molecule ERα inhibitor.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
50MG ¥6116 有现货
100MG ¥10044 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    BHPI
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    BHPI is a potent, noncompetitive small molecule ERα inhibitor.
  • 产品描述
    BHPI is a potent, noncompetitive small molecule ERα inhibitor (biomodulator) that selectively blocks proliferation of drug-resistant ERα-positive breast and ovarian cancer cells; distorts this normal action of E2–ERα and induces a massive and sustained ERα-dependent activation of the unfolded protein response (UPR), persistent inhibition of protein synthesis, converting UPR activation from cytoprotective to cytotoxic; completely blocked proliferation of ERα+ cancer cells at 100-1000 nM, induces tumor regression in mouse xenograft of MCF-7 cells.
  • 同义词
    BHPI;
  • 通路
    Endocrinology/Hormones
  • 靶点
    Estrogen Receptor/ERR
  • 受体
    Estrogen Receptor/ERR
  • 研究领域
    Cancer
  • 适应症
    ——

化学信息

  • CAS Number
    56632-39-4
  • 分子量
    331.36
  • 分子式
    C21H17NO3
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO: ≥150 mg/mL
  • SMILES
    O=C1NC2=C(C=CC=C2C)C1(C3=CC=C(O)C=C3)C4=CC=C(O)C=C4
  • 化学全称
    2H-Indol-2-one, 1,3-dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl-

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Andruska ND, et al. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4737-42.
2. Zheng X, et al. Oncotarget. 2016 Jul 24;9(19):14741-14753.
3. Mao C, et al. Sci Rep. 2016 Oct 7;6:34753.
产品手册
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