BHPI
CAS No. 56632-39-4
BHPI ( BHPI; )
产品货号. M15059 CAS No. 56632-39-4
BHPI is a potent, noncompetitive small molecule ERα inhibitor.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
50MG | ¥6116 | 有现货 |
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100MG | ¥10044 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称BHPI
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述BHPI is a potent, noncompetitive small molecule ERα inhibitor.
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产品描述BHPI is a potent, noncompetitive small molecule ERα inhibitor (biomodulator) that selectively blocks proliferation of drug-resistant ERα-positive breast and ovarian cancer cells; distorts this normal action of E2–ERα and induces a massive and sustained ERα-dependent activation of the unfolded protein response (UPR), persistent inhibition of protein synthesis, converting UPR activation from cytoprotective to cytotoxic; completely blocked proliferation of ERα+ cancer cells at 100-1000 nM, induces tumor regression in mouse xenograft of MCF-7 cells.
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同义词BHPI;
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通路Endocrinology/Hormones
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靶点Estrogen Receptor/ERR
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受体Estrogen Receptor/ERR
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研究领域Cancer
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适应症——
化学信息
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CAS Number56632-39-4
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分子量331.36
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分子式C21H17NO3
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纯度>98% (HPLC)
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溶解度DMSO: ≥150 mg/mL
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SMILESO=C1NC2=C(C=CC=C2C)C1(C3=CC=C(O)C=C3)C4=CC=C(O)C=C4
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化学全称2H-Indol-2-one, 1,3-dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Andruska ND, et al. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4737-42.
2. Zheng X, et al. Oncotarget. 2016 Jul 24;9(19):14741-14753.
3. Mao C, et al. Sci Rep. 2016 Oct 7;6:34753.
2. Zheng X, et al. Oncotarget. 2016 Jul 24;9(19):14741-14753.
3. Mao C, et al. Sci Rep. 2016 Oct 7;6:34753.
产品手册
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