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SAR439859
CAS No. 2114339-57-8
SAR439859 ( —— )
产品货号. M23964 CAS No. 2114339-57-8
SAR439859 is an orally active, nonsteroidal and selective degrader of estrogen receptor (SERD).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2535 | 有现货 |
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| 10MG | ￥3872 | 有现货 |
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| 25MG | ￥6391 | 有现货 |
|
| 50MG | ￥8748 | 有现货 |
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| 100MG | ￥11988 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称SAR439859
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述SAR439859 is an orally active, nonsteroidal and selective degrader of estrogen receptor (SERD).
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产品描述SAR439859 is an orally active, nonsteroidal and selective degrader of estrogen receptor (SERD). SAR439859 is a potent antagonist of ER (with an EC50 of 0.2 nM for ERα degradation).
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同义词——
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通路Endocrinology/Hormones
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靶点Estrogen Receptor/ERR
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受体ERα
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研究领域——
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适应症——
化学信息
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CAS Number2114339-57-8
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分子量554.5
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分子式C31H30Cl2FNO3
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纯度>98% (HPLC)
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溶解度DMSO:125 mg/mL?(225.44 mM;?Need ultrasonic)
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SMILESC1CC2=C(C=CC(=C2)C(=O)O)C(=C(C1)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)O[C@H]5CCN(C5)CCCF
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.El-Ahmad Y, et al. Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer. J Med Chem. 2019 Nov 27.
产品手册
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