27-Hydroxycholesterol
CAS No. 20380-11-4
27-Hydroxycholesterol ( —— )
产品货号. M29620 CAS No. 20380-11-4
27-Hydroxycholesterol is a selective modulator of estrogen receptor and an agonist of the liver X receptor.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥1393 | 有现货 |
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10MG | ¥2066 | 有现货 |
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25MG | ¥3507 | 有现货 |
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50MG | ¥5087 | 有现货 |
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100MG | 获取报价 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称27-Hydroxycholesterol
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述27-Hydroxycholesterol is a selective modulator of estrogen receptor and an agonist of the liver X receptor.
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产品描述27-Hydroxycholesterol is a selective modulator of estrogen receptor and an agonist of the liver X receptor.(In Vitro):27-Hydroxycholesterol, through estrogen receptor activation, triggers a deleterious effect in prostate cancer cell lines. 27-Hydroxycholesterol significantly increases cell proliferation of LNCaP and PC3 cells and this effect can be attenuated by estrogen receptor inhibitors . 27-Hydroxycholesterol is an endogenous selective estrogen receptor modulator that displays significant partial agonist activity in a variety of cellular models of estrogen receptor action. It positively regulates both gene transcription and cell proliferation in cellular models of breast cancer . 27-Hydroxycholesterol is an oxysterol produced from cholesterol by the monooxygenase CYP27A1, which regulates intracellular cholesterol homeostasis. 27-Hydroxycholesterol levels can be modulated by statins or direct inhibition of CYP27A1, thereby attenuating its pro-tumorigenic activities . 27-hydroxylation of cholesterol is an important pathway for LXR activation in response to cholesterol overload .
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同义词——
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通路Endocrinology/Hormones
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靶点Estrogen Receptor/ERR
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受体Estrogen/progestogen Receptor
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研究领域——
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适应症——
化学信息
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CAS Number20380-11-4
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分子量402.7
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分子式C27H46O2
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纯度>98% (HPLC)
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溶解度——
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SMILES[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCC[C@@H](C)CO
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
产品手册
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