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27-Hydroxycholesterol

CAS No. 20380-11-4

27-Hydroxycholesterol ( —— )

产品货号. M29620 CAS No. 20380-11-4

27-Hydroxycholesterol is a selective modulator of estrogen receptor and an agonist of the liver X receptor.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥1393 有现货
10MG ¥2066 有现货
25MG ¥3507 有现货
50MG ¥5087 有现货
100MG 获取报价 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    27-Hydroxycholesterol
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    27-Hydroxycholesterol is a selective modulator of estrogen receptor and an agonist of the liver X receptor.
  • 产品描述
    27-Hydroxycholesterol is a selective modulator of estrogen receptor and an agonist of the liver X receptor.(In Vitro):27-Hydroxycholesterol, through estrogen receptor activation, triggers a deleterious effect in prostate cancer cell lines. 27-Hydroxycholesterol significantly increases cell proliferation of LNCaP and PC3 cells and this effect can be attenuated by estrogen receptor inhibitors . 27-Hydroxycholesterol is an endogenous selective estrogen receptor modulator that displays significant partial agonist activity in a variety of cellular models of estrogen receptor action. It positively regulates both gene transcription and cell proliferation in cellular models of breast cancer . 27-Hydroxycholesterol is an oxysterol produced from cholesterol by the monooxygenase CYP27A1, which regulates intracellular cholesterol homeostasis. 27-Hydroxycholesterol levels can be modulated by statins or direct inhibition of CYP27A1, thereby attenuating its pro-tumorigenic activities . 27-hydroxylation of cholesterol is an important pathway for LXR activation in response to cholesterol overload .
  • 同义词
    ——
  • 通路
    Endocrinology/Hormones
  • 靶点
    Estrogen Receptor/ERR
  • 受体
    Estrogen/progestogen Receptor
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    20380-11-4
  • 分子量
    402.7
  • 分子式
    C27H46O2
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    [H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCC[C@@H](C)CO
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

产品手册
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