Depofemin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Estradiol cypionate 是雌二醇的 17 β-环戊基丙酸酯，可通过雌激素受体抑制 ET-1 合成。

Estradiol cypionate is the 17 β-cyclopentylpropinate ester of estradiol, which inhibits ET-1 synthesis via estrogen receptor.

Western Blot Analysis Cell Line:MGC803, SGC7901, and BGC823 cells Concentration:10-25 μM Incubation Time:48 h Result:Increased protein level of cleaved caspase-3 and PARP.Decreased protein levels of AKT, p-AKT, p-mTOR, p-S6K, and p-4E-BP1.

Animal Model:MGC803 nude mice tumor model.Dosage:50-100?mg/kg Administration:i.p., every other day Result:Inhibited tumor growth.Increased Cleaved caspase-3 expression, decreased Ki67, AKT and p-AKT in tumors.

Estradiol cypionate | β-Estradiol 17-cypionate

Endocrinology/Hormones

Estrogen Receptor/ERR

ER

Endocrinology

——

313-06-4

396.58

C26H36O3

>98% (HPLC)

Ethanol: 55 mg/mL (138.69 mM); DMSO: 79 mg/mL (199.21 mM)

O=C(O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=C(C=CC(O)=C4)[C@@]3([H])CC[C@]12C)CCC5CCCC5

Cyclopentanepropionic acid, 3-hydroxyestra-1,3,5(10)-trien-17beta-yl ester

(-20℃)

With Ice Pack

≥ 2 years