021-51111890
购物车（）
sales@molnova.cn
AZD9496
CAS No. 1639042-08-2
AZD9496 ( AZD-9496 )
产品货号. M12477 CAS No. 1639042-08-2
A potent, selective estrogen receptor downregulator (SERD) with ER downregulation pIC50 of 9.68.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥575 | 有现货 |
|
| 5MG | ￥956 | 有现货 |
|
| 10MG | ￥1604 | 有现货 |
|
| 25MG | ￥2997 | 有现货 |
|
| 50MG | ￥4439 | 有现货 |
|
| 100MG | ￥6415 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称AZD9496
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述A potent, selective estrogen receptor downregulator (SERD) with ER downregulation pIC50 of 9.68.
-
产品描述A potent, selective estrogen receptor downregulator (SERD) with ER downregulation pIC50 of 9.68; shows pM equipotent binding to both ERα and ERβ isoforms, highly selective binding compared with progesterone (～650-fold), glucocorticoid (～11,223-fold), and androgen (～36,375-fold) receptor LBDs; downregulator of ERα in vitro and in vivo in ER-positive models of breast cancer and orally available. Breast Cancer Phase 1 Clinical
-
同义词AZD-9496
-
通路Endocrinology/Hormones
-
靶点Estrogen Receptor/ERR
-
受体ERα
-
研究领域Cancer
-
适应症Breast Cancer
化学信息
-
CAS Number1639042-08-2
-
分子量442.47
-
分子式C25H25F3N2O2
-
纯度>98% (HPLC)
-
溶解度DMSO: ≥ 104.5 mg/mL
-
SMILESCC1CC2=C(C(N1CC(C)(C)F)C3=C(C=C(C=C3F)C=CC(=O)O)F)NC4=CC=CC=C24
-
化学全称2-Propenoic acid, 3-[3,5-difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]phenyl]-, (2E)-
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. De Savi C, et al. J Med Chem. 2015 Oct 22;58(20):8128-40.
2. Weir HM, et al. Cancer Res. 2016 Jun 1;76(11):3307-18.
3. Toy W, et al. Cancer Discov. 2017 Mar;7(3):277-287.
2. Weir HM, et al. Cancer Res. 2016 Jun 1;76(11):3307-18.
3. Toy W, et al. Cancer Discov. 2017 Mar;7(3):277-287.
产品手册
关联产品
-
Allylestrenol
Allylestrenol is a synthetic steroid with progestational activity.
-
Lynestrenol
Lynestrenol is a synthetic progestational hormone is the progesterone receptor?agonist.
-
GDC-0810
GDC-0810 (ARN-810, Brilanestrant) is a non-steroidal, orally bioavailable selective estrogen receptor degrader (SERD) with IC50 of 0.7 nM (ER-α degradation).
