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AZD9496

CAS No. 1639042-08-2

AZD9496 ( AZD-9496 )

产品货号. M12477 CAS No. 1639042-08-2

A potent, selective estrogen receptor downregulator (SERD) with ER downregulation pIC50 of 9.68.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥575 有现货
5MG ¥956 有现货
10MG ¥1604 有现货
25MG ¥2997 有现货
50MG ¥4439 有现货
100MG ¥6415 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    AZD9496
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    A potent, selective estrogen receptor downregulator (SERD) with ER downregulation pIC50 of 9.68.
  • 产品描述
    A potent, selective estrogen receptor downregulator (SERD) with ER downregulation pIC50 of 9.68; shows pM equipotent binding to both ERα and ERβ isoforms, highly selective binding compared with progesterone (~650-fold), glucocorticoid (~11,223-fold), and androgen (~36,375-fold) receptor LBDs; downregulator of ERα in vitro and in vivo in ER-positive models of breast cancer and orally available. Breast Cancer Phase 1 Clinical
  • 同义词
    AZD-9496
  • 通路
    Endocrinology/Hormones
  • 靶点
    Estrogen Receptor/ERR
  • 受体
    ERα
  • 研究领域
    Cancer
  • 适应症
    Breast Cancer

化学信息

  • CAS Number
    1639042-08-2
  • 分子量
    442.47
  • 分子式
    C25H25F3N2O2
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO: ≥ 104.5 mg/mL
  • SMILES
    CC1CC2=C(C(N1CC(C)(C)F)C3=C(C=C(C=C3F)C=CC(=O)O)F)NC4=CC=CC=C24
  • 化学全称
    2-Propenoic acid, 3-[3,5-difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]phenyl]-, (2E)-

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. De Savi C, et al. J Med Chem. 2015 Oct 22;58(20):8128-40.
2. Weir HM, et al. Cancer Res. 2016 Jun 1;76(11):3307-18.
3. Toy W, et al. Cancer Discov. 2017 Mar;7(3):277-287.
产品手册
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