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Diarylpropionitrile

CAS No. 1428-67-7

Diarylpropionitrile ( DPN )

产品货号. M11807 CAS No. 1428-67-7

Diarylpropionitrile (DPN) is a non-steroidal estrogen receptor β(ERβ) selective ligand.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥259 有现货
10MG ¥421 有现货
25MG ¥875 有现货
50MG ¥1604 有现货
100MG ¥2851 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Diarylpropionitrile
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Diarylpropionitrile (DPN) is a non-steroidal estrogen receptor β(ERβ) selective ligand.
  • 产品描述
    Diarylpropionitrile (DPN) is a non-steroidal estrogen receptor β(ERβ) selective ligand, demonstrates the neuroprotective effects against 10 0M Aβ1-42-induced oxidative stress and inflammation in primary rat cortical cell culture; (1-100 nM) significantly decreases neuronal cell death by increasing cell viability through a significant attenuation in the reactive oxygen species level, downregulation of pro-apoptotic activated caspase-3 and Bax, and upregulation of anti-apoptotic Bcl-2; decreases the expression levels of IL-1β and IL-6; inhibits medulloblastoma development via anti-proliferative and pro-apototic pathways.
  • 同义词
    DPN
  • 通路
    Endocrinology/Hormones
  • 靶点
    Estrogen Receptor/ERR
  • 受体
    Estrogen Receptor/ERR
  • 研究领域
    Neurological Disease
  • 适应症
    ——

化学信息

  • CAS Number
    1428-67-7
  • 分子量
    239.27
  • 分子式
    C15H13NO2
  • 纯度
    >98% (HPLC)
  • 溶解度
    10 mM in DMSO
  • SMILES
    C1=CC(=CC=C1CC(C#N)C2=CC=C(C=C2)O)O
  • 化学全称
    Benzenepropanenitrile, 4-hydroxy-α-(4-hydroxyphenyl)-

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Suwanna N, et al. Neurosci Lett. 2014 Aug 22;578:44-9.
2. Khalaj AJ, et al. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19125-30.
3. Mancuso M, et al. Cancer Lett. 2011 Sep 28;308(2):197-202.
4. Motylewska E, et al. Cancer Lett. 2009 Apr 8;276(1):68-73.
产品手册
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