Diarylpropionitrile
CAS No. 1428-67-7
Diarylpropionitrile ( DPN )
产品货号. M11807 CAS No. 1428-67-7
Diarylpropionitrile (DPN) is a non-steroidal estrogen receptor β(ERβ) selective ligand.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥259 | 有现货 |
|
10MG | ¥421 | 有现货 |
|
25MG | ¥875 | 有现货 |
|
50MG | ¥1604 | 有现货 |
|
100MG | ¥2851 | 有现货 |
|
200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称Diarylpropionitrile
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述Diarylpropionitrile (DPN) is a non-steroidal estrogen receptor β(ERβ) selective ligand.
-
产品描述Diarylpropionitrile (DPN) is a non-steroidal estrogen receptor β(ERβ) selective ligand, demonstrates the neuroprotective effects against 10 0M Aβ1-42-induced oxidative stress and inflammation in primary rat cortical cell culture; (1-100 nM) significantly decreases neuronal cell death by increasing cell viability through a significant attenuation in the reactive oxygen species level, downregulation of pro-apoptotic activated caspase-3 and Bax, and upregulation of anti-apoptotic Bcl-2; decreases the expression levels of IL-1β and IL-6; inhibits medulloblastoma development via anti-proliferative and pro-apototic pathways.
-
同义词DPN
-
通路Endocrinology/Hormones
-
靶点Estrogen Receptor/ERR
-
受体Estrogen Receptor/ERR
-
研究领域Neurological Disease
-
适应症——
化学信息
-
CAS Number1428-67-7
-
分子量239.27
-
分子式C15H13NO2
-
纯度>98% (HPLC)
-
溶解度10 mM in DMSO
-
SMILESC1=CC(=CC=C1CC(C#N)C2=CC=C(C=C2)O)O
-
化学全称Benzenepropanenitrile, 4-hydroxy-α-(4-hydroxyphenyl)-
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
2. Khalaj AJ, et al. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19125-30.
3. Mancuso M, et al. Cancer Lett. 2011 Sep 28;308(2):197-202.
4. Motylewska E, et al. Cancer Lett. 2009 Apr 8;276(1):68-73.
产品手册
关联产品
-
Etonogestrel
Etonogestrel is a steroidal progestin used in hormonal contraceptives.
-
WAY-200070
WAY-200070 is a potent, highly selective ERβ agonist with IC50 of 3 nM, displays 68-fold selectivity over ERα (IC50=260 nM).
-
Estradiol benzoate
Estradiol benzoate is an estradiol analog which binds to the human, murine and chicken ERα with IC50 of 22-28 nM.