4-Hydroxyestrone ( —— )

产品货号. M28696 CAS No. 3131-23-5

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产品名称

4-Hydroxyestrone
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本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

4-Hydroxyestrone, an endogenous estrogen metabolite, can strongly protect neuronal cells against oxidative damage.
产品描述

4-Hydroxyestrone, an endogenous estrogen metabolite, can strongly protect neuronal cells against oxidative damage.(In Vitro):Using immortalized mouse hippocampal neuronal cells as an in vitro model, 4-Hydroxyestrone, an estrone metabolite with little estrogenic activity, is found to have the strongest neuroprotective effect against oxidative neurotoxicity among 25 endogenous estrogen metabolites tested, and its protective effect is stronger than 17β-estradiol. Similarly, 4-Hydroxyestrone also exerts a stronger protective effect than 17β-estradiol against kanic acid-induced hippocampal oxidative damage in rats.(In Vivo):4-Hydroxyestrone also exerts a stronger protective effect than 17β-estradiol against kanic acid-induced hippocampal oxidative damage in rats. Neuroprotection by 4-hydroxyestrone involves increased cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53. Analysis of brain microsomal enzymes shows that estrogen 4-hydroxylation is the main metabolic pathway in the central nervous system.
同义词

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通路

Endocrinology/Hormones
靶点

Estrogen Receptor/ERR
受体

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研究领域

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适应症

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1.HUMBER LG. AGENTS AFFECTING LIPID METABOLISM. XII. N,N'-DISUBSTITUTED CYCLOHEXANE-1,4-BIS(METHYLAMINES). J Med Chem. 1964 Nov;7:826-30.

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