AU1 ( GSK 1379725A )

产品货号. M12752 CAS No. 1802251-00-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

AU1
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

AU1 (GSK 1379725A) is the first selective small molecule inhibitor of BPTF bromodomain (bromodomain PHD finger transcription factor) with Kd of 2.8 uM in a cell-based reporter assay.
产品描述

AU1 (GSK 1379725A) is the first selective small molecule inhibitor of BPTF bromodomain (bromodomain PHD finger transcription factor) with Kd of 2.8 uM in a cell-based reporter assay, shows no binding activity for Brd4; interferes with its regulatory activity in cultured cells.
同义词

GSK 1379725A
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

Bromodomain
研究领域

Other Indications
适应症

——

CAS Number

1802251-00-8
分子量

450.47
分子式

C23H23FN6O3
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C(OC)C1=CC=CC(NC(NC2CN(C3=NC(NC4=CC=C(F)C=C4)=NC=C3)CC2)=O)=C1
化学全称

Benzoic acid, 3-[[[[1-[2-[(4-fluorophenyl)amino]-4-pyrimidinyl]-3-pyrrolidinyl]amino]carbonyl]amino]-, methyl ester

1. Urick AK, et al. ACS Chem Biol. 2015 Oct 16;10(10):2246-56.

计算器

产品手册

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