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GSK-340
CAS No. 2222509-79-5
GSK-340 ( GSK340 | GSK 340 )
产品货号. M13548 CAS No. 2222509-79-5
GSK-340 是 BET 家族第二溴结构域 (BD2) 的有效、选择性抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称GSK-340
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述GSK-340 是 BET 家族第二溴结构域 (BD2) 的有效、选择性抑制剂。
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产品描述GSK-340 is a potent, selective inhibitor of second bromodomains of the BET family (BD2) with pKd of 8.18, 7.49, 7.72 and 7.68 for BRD4 BD2, BRD3 BD2, BRD2 BD2 and BRD4T BD2, respectively; displays 229-, 40-, 48- and 91-fold selectivity over the responding BD1, >100-fold selectivity over TAF1, WRD9, ATAD2A/B and other bromodomains (pKd<5.0); inhibits BRD4 BD2, BRD3 BD2, BRD2 BD2 and BRD4T BD2 with pIC50 of 7.2, 6.5, 7.3 and 6.7, respectively; inhibits release of the MCP-1 cytokine in human PBMCs (pIC50=7.4) and whole blood; GSK-340 is an useful in vitro tool molecule for investigation into the biological role of the BD2 domains.
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体外实验——
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体内实验——
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同义词GSK340 | GSK 340
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通路Chromatin/Epigenetic
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靶点Bromodomain
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受体Bromodomain
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研究领域——
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适应症——
化学信息
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CAS Number2222509-79-5
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分子量417.553
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分子式C26H31N3O2
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称(S)-1-(2-cyclopropyl-4-(2-(hydroxymethyl)benzyl)-6-(1,2,3,6-tetrahydropyridin-4-yl)-3,4-dihydroquinoxalin-1(2H)-yl)ethan-1-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Law RP, et al. J Med Chem. 2018 May 3. doi: 10.1021/acs.jmedchem.7b01666.
