ZL0420 ( ZL-0420;ZL 0420 )

产品货号. M13567 CAS No. 2229039-45-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

ZL0420
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

ZL0420 is a potent, highly selective BRD4 inhibitor with IC50 of 27 and 32 nM for BRD4-BD1 and BRD4-BD2, respectively.
产品描述

ZL0420 is a potent, highly selective BRD4 inhibitor with IC50 of 27 and 32 nM for BRD4-BD1 and BRD4-BD2, respectively; displays selectivity over BRD2, BRD3, and BRDT (BRD2-BD1 and BRD2-BD2, IC50=803 and 1736 nM); disrupts the BRD4 complex with Pol II and histones, inhibits poly(I:C)-induced expression of innate immune genes IL6 and CIG5 in human small airway epithelial cells (hSAECs) (IC50=0.54 and 0.51 uM); blocks Poly(I:C)-induced inflammation and neutrophilia in vivo.
同义词

ZL-0420;ZL 0420
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

Bromodomain
研究领域

——
适应症

——

CAS Number

2229039-45-4
分子量

296.33
分子式

C16H16N4O2
纯度

>98% (HPLC)
溶解度

——
SMILES

CC1=C(O)C=C(N)C(/N=N/C2=CC(CCC(N3)=O)=C3C=C2)=C1
化学全称

(E)-6-((2-amino-4-hydroxy-5-methylphenyl)diazenyl)-3,4-dihydroquinolin-2(1H)-one

1. Tian B, et al. Cell Rep. 2018 Apr 24;23(4):1138-1151.
2. Liu Z, et al. Eur J Med Chem 2018 May 10;151:450-461.

计算器

产品手册

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