CN750 ( CN-750;CN 750 )

产品货号. M13320 CAS No. 2098711-72-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

CN750
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

CN750 (CN-750) is novel BRD4 (BD1, 2) inhibitor with IC50 of 44 nM, MV4-11 IC50 of 0.54 uM.
产品描述

CN750 (CN-750) is novel BRD4 (BD1, 2) inhibitor with IC50 of 44 nM, MV4-11 IC50 of 0.54 uM; shows Kd values of 33, 27, 24, 21, 20, 21, 18, 50, 20, 67, and 160 nM for BRD2 (BD1), BRD2 (BD1,2), BRD2 (BD2), BRD3 (BD1), BRD3 (BD1,2), BRD3 (BD2), BRD4 (BD1), BRD4 (BD2), BRDT (BD1), BRDT (BD1,2), and BRDT (BD2), respectively; CN750 is a pan BET family inhibitor.
同义词

CN-750;CN 750
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

Bromodomain
研究领域

——
适应症

——

CAS Number

2098711-72-7
分子量

532.09
分子式

C29H34ClN7O
纯度

>98% (HPLC)
溶解度

——
SMILES

CN1C=C(C=CC1=O)C2=CC3=C(C=C2)N=C(N=C3NCC4=CC(=CC=C4)Cl)N5CCN(CC5)CCN(C)C
化学全称

5-(4-((3-chlorobenzyl)amino)-2-(4-(2-(dimethylamino)ethyl)piperazin-1-yl)quinazolin-6-yl)-1-methylpyridin-2(1H)-one

1. Yang SM, et al. Bioorg Med Chem Lett. 2018 Nov 15;28(21):3483-3488.

计算器

产品手册

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