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AG-636

CAS No. 1623416-31-8

AG-636 ( —— )

产品货号. M23718 CAS No. 1623416-31-8

AG-636 is a potent, reversible, selective and orally active DHODH inhibitor(IC50 of 17 nM). It has strong anticancer effects.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥1345 有现货
10MG ¥2211 有现货
25MG ¥4496 有现货
50MG ¥6464 有现货
100MG ¥8829 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    AG-636
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    AG-636 is a potent, reversible, selective and orally active DHODH inhibitor(IC50 of 17 nM). It has strong anticancer effects.
  • 产品描述
    AG-636 is a potent, reversible, selective and orally active DHODH inhibitor(IC50 of 17 nM). It has strong anticancer effects.
  • 同义词
    ——
  • 通路
    Metabolic Enzyme/Protease
  • 靶点
    Dehydrogenase
  • 受体
    DHODH;DNA/RNA Synthesis
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    1623416-31-8
  • 分子量
    343.4
  • 分子式
    C21H17N3O2
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO:31.25 mg/mL (91.01 mM; Need ultrasonic)
  • SMILES
    O=C(C1=C(N(C)N=N2)C2=CC(C3=CC=C(C4=CC=CC=C4C)C=C3)=C1)O
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Gabrielle McDonald, et al. Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase. Mol Cancer Ther. 2020 Dec;19(12):2502-2515.
产品手册
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