AG-636
CAS No. 1623416-31-8
AG-636 ( —— )
产品货号. M23718 CAS No. 1623416-31-8
AG-636 is a potent, reversible, selective and orally active DHODH inhibitor(IC50 of 17 nM). It has strong anticancer effects.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥1345 | 有现货 |
|
10MG | ¥2211 | 有现货 |
|
25MG | ¥4496 | 有现货 |
|
50MG | ¥6464 | 有现货 |
|
100MG | ¥8829 | 有现货 |
|
200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称AG-636
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述AG-636 is a potent, reversible, selective and orally active DHODH inhibitor(IC50 of 17 nM). It has strong anticancer effects.
-
产品描述AG-636 is a potent, reversible, selective and orally active DHODH inhibitor(IC50 of 17 nM). It has strong anticancer effects.
-
同义词——
-
通路Metabolic Enzyme/Protease
-
靶点Dehydrogenase
-
受体DHODH;DNA/RNA Synthesis
-
研究领域——
-
适应症——
化学信息
-
CAS Number1623416-31-8
-
分子量343.4
-
分子式C21H17N3O2
-
纯度>98% (HPLC)
-
溶解度DMSO:31.25 mg/mL (91.01 mM; Need ultrasonic)
-
SMILESO=C(C1=C(N(C)N=N2)C2=CC(C3=CC=C(C4=CC=CC=C4C)C=C3)=C1)O
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Gabrielle McDonald, et al. Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase. Mol Cancer Ther. 2020 Dec;19(12):2502-2515.
产品手册
关联产品
-
6PGD-IN-S3
6PGD-IN-S3 is an inhibitor of 6-phosphogluconate dehydrogenase (6PGD).
-
AGI-6780
AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant with IC50 of 23 nM.
-
Atovaquone
Atovaquone is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia.