Methotrexate ( Amethopterin; CL 14,377; EMT 25299; MTX; NSC 740; R 9985 )

产品货号. M15186 CAS No. 59-05-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Methotrexate
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Methotrexate, a folate antagonist, is a potent anti-inflammatory agent when used weekly in low concentrations.
产品描述

Methotrexate, a folate antagonist, is a potent anti-inflammatory agent when used weekly in low concentrations, the anti-phlogistic action of which is due to increased adenosine release at inflamed sites. Studies have demonstrated that methotrexate polyglutamates are active inhibitors of several enzymatic reactions, including dihydrofolate reductase.
同义词

Amethopterin; CL 14,377; EMT 25299; MTX; NSC 740; R 9985
通路

Metabolic Enzyme/Protease
靶点

Dehydrogenase
受体

hDHFR
研究领域

Inflammation/Immunology
适应症

——

CAS Number

59-05-2
分子量

454.44
分子式

C20H22N8O5
纯度

>98%(HPLC)
溶解度

DMSO: 90 mg/mL warmed (198.04 mM)
SMILES

CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
化学全称

——

1.Al-Rashood ST, et al. Bioorg Med Chem. 2006 Dec 15;14(24):8608-2

计算器

产品手册

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