GluR
L-Glutamate is the predominant excitatory neurotransmitter in vertebrate nervous systems. Receptors for glutamate have been implicated in neuronal plasticity and higher neuronal functions like memory and learning. The ligand gated ionotropic glutamate receptor subtypes are traditionally defined by specific agonists. Currently four genes (GluR A, B, C and D) are known that code for the AMPA subtypes of glutamate receptors. Recombinant expression of wild type and mutated sequences identified a critical residue in the putative TM2 channel-lining segment that controls Ca2+ ion permeability. The arginine (R) found in GluR B subunits at that position renders AMPA channels impermeable for Ca2+ ions, whereas glutamine (Q) containing GluR A, C and D subunits give rise to Ca2+ permeable channels. Glutamate is the primary excitatory neurotransmitter in the central nervous system (CNS), and glutamate takes its effect in the CNS through metabotropic and ionotropic glutamate receptors (mGluRs and iGluRs, respectively). Genome-wide and candidate gene association study indicated that glutamate receptors (GluRs) were implicated in ADHD.
References
1.Schoepfer R,et al. Prog Neurobiol. 1994;42(2):353–357.
References
1.Schoepfer R,et al. Prog Neurobiol. 1994;42(2):353–357.
Neuroscience
GluR
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KM02894
产品货号 : M36968
cas no: 116850-74-9
KM02894 是一种谷氨酸释放抑制剂。癌细胞释放高水平的谷氨酸,能够破坏正常的骨转换,并可能导致癌症引起的骨痛。KM02894 可用于肿瘤相关研究。 -
Pomaglumetad methionil hydrochloride
产品货号 : M35610
cas no: 635318-26-2
Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) 是一种选择性 mGlu2/3 受体激动剂 LY404039 的蛋氨酸前药,具有口服活性。Pomaglumetad methionil hydrochloride 可用于精神分裂症的研究。 -
1H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aR)-
产品货号 : M35385
cas no: 175340-21-3
1H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aR)- is a low activity isomer of S 18986. S 18986 is a AMPA receptor positive modulator with EC2 (Concentration that doubles the intensity of the AMPA-induced current) of 35 μM. -
CX717
产品货号 : M35376
cas no: 867276-98-0
CX 717 是AMPA 受体的正变构调节剂。具有抗抑郁样作用。可用于成人注意力缺陷多动障碍(ADHD)的研究。 -
FPTQ B
产品货号 : M35294
cas no: 864863-72-9
FPTQ 是一种有效的 mGluR1 拮抗剂,抑制人和鼠的 IC50 值分别为 6 nM 和 1.4 nM。FPTQ 具有抗氧化、抗炎作用。