Norepinephrine
Norepinephrine is the predominant endogenous sympathetic amine acting in all populations of adrenoreceptors. There is a common misperception that this amine is predominantly an α-agonist. Norepinephrine exhibits sympathetic activity over an expanding population of adrenoreceptors on the circulation (α1A and α1B, α2A, α2B and α2C, β1, β2 and β3), acting centrally on the myocardium, on the arterial (conduit) circulation and on the venous (capacitance) circulation. NE exerts its actions on target cells by binding to and activating adrenergic receptors. The target cell expression of different receptor types determines the ultimate cellular effect, and thus NE has different actions on different cell types. The signal is terminated by the removal of NE through distinct uptake mechanisms that may eventually be followed by enzymatic degradation. Part of the NE is transported by the monoamine vesicular transporter into synaptic vesicles to be further released upon stimuli, but uptake may be followed by rapid degradation to various metabolites through monoamine oxidase (MAO) or catechol-O-methyl transferase (COMT) enzymes. In neurons, MAO converts NE to the corresponding aldehyde which is then nonenzymatically further oxidized.
Neuroscience
Norepinephrine
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Losulazine
产品货号 : M36190
cas no: 72141-57-2
Losulazine is a peripheral sympathetic antihypertensive compound that can be taken orally. Losulazine causes relatively modest, transient depletion of dopamine and norepinephrine in brain regions protected by the blood-brain barrier. -
Fezolamine
产品货号 : M36171
cas no: 80410-36-2
Fezolamine is a novel orally available non-tricyclic compound with antidepressant activity. It is three to two times more selective in blocking synaptosomal uptake of [3H]norepinephrine than uptake of [4H]3-hydroxytryptamine or [3H]dopamine in vitro. It blocked the inhibitory effects of rifampicin and tetraphenyl in classical behavioral tests using monoamine-depleted animals. -
Tampramine
产品货号 : M36000
cas no: 83166-17-0
Tampramine is a selective norepinephrine reuptake inhibitor that shows a low affinity for adrenergic, histaminergic and muscarinic receptors. Tampramine is a candidate compound for the treatment of forced swimming test (FST) depression. -
Cianopramine
产品货号 : M34061
cas no: 66834-24-0
Cianopramine (Ro 112465) is a selective 5-hydroxytryptamine uptake inhibitor and a tricyclic antidepressant used in the study of neurological disorders. -
(S)-Viloxazine Hydrochloride
产品货号 : M33815
cas no: 56287-61-7
(S)-Viloxazine Hydrochloride, the S-isomer of Viloxazine. Viloxazine is a selective norepinephrine reuptake inhibitor (NRI) that can be used as an antidepressant.