CX717

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CX 717 是AMPA 受体的正变构调节剂。具有抗抑郁样作用。可用于成人注意力缺陷多动障碍（ADHD）的研究。

CX 717 is a positive allosteric modulator of AMPA receptor. Antidepressant-like effect. CX 717 can be used for the research of adult attention deficit hyperactivity disorder (ADHD).

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CX 717 (CX717; 20 mg/kg) has a rapid (30 min) but short-lasting (up to 24 h) antidepressantlike effect in the forced swim test.CX 717 also produces a rapid (up to 1 h) increase of brain-derived neurotrophic factor (BDNF) and a more sustained (up to 6 h) increase of p11. Intra-cortical infusion of CX 717 (85 mM) increases the efflux of noradrenaline, dopamine, and serotonin, but not glutamate.Animal Model:Male Sprague-Dawley rats weighing 280-350 g Dosage:20 mg/kg (administered at 1 mL/kg) Administration:Intraperitoneal (i.p.) injection Result:Evoked antidepressant-like effects (20 mg/kg, i.p.) did not alter the extracellular concentrations of noradrenaline (NA), dopamine (DA), serotonin (5-HT) and glutamate in the medial prefrontal cortex (mPFC).

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Neuroscience

GluR

GluR

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867276-98-0

233.23

C11H11N3O3

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 50 mg/mL (214.39 mM; 超声助溶 (<60°C)

O=C(N1CCOCC1)c1ccc2nonc2c1

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(-20℃)

With Ice Pack

≥ 2 years