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YM-201636
CAS No. 371942-69-7
YM-201636 ( YM 201636 | YM201636 )
产品货号. M14284 CAS No. 371942-69-7
YM-201636 是一种有效的选择性 PIKfyve 抑制剂，IC50 为 33 nM，即使在 10 uM 时也不会抑制 Iiγ/Iα 型 PtdInsP 激酶 (p110α IC50=3.3 uM)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥470 | 有现货 |
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| 5MG | ￥786 | 有现货 |
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| 10MG | ￥1482 | 有现货 |
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| 25MG | ￥3062 | 有现货 |
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| 50MG | ￥4795 | 有现货 |
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| 100MG | ￥6845 | 有现货 |
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| 500MG | ￥14013 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称YM-201636
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述YM-201636 是一种有效的选择性 PIKfyve 抑制剂，IC50 为 33 nM，即使在 10 uM 时也不会抑制 Iiγ/Iα 型 PtdInsP 激酶 (p110α IC50=3.3 uM)。
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产品描述YM-201636 is a potent, selective PIKfyve inhibitor with IC50 of 33 nM, does not inhibits type Iiγ/Iα PtdInsP kinases even at 10 uM (p110α IC50=3.3 uM); shows insensitivity against yeast orthologue of PIKfyve, Fab1; significantly decreases the production of PtdIns(3,5)P2 by 80% in serum-starved NIH3T3 cells with no effect on serum-stimulated PKB Ser 473 phosphorylation at 0.8 uM; inhibits basal and insulin-activated 2-deoxyglucose uptake withIC50 of 54 nM; significantly reduces retroviruses budding from cells; blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells.
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体外实验——
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体内实验——
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同义词YM 201636 | YM201636
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通路PI3K/Akt/mTOR signaling
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靶点PIKfyve
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受体p110α|PIKfyve
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研究领域Cancer
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适应症——
化学信息
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CAS Number371942-69-7
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分子量467.4793
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分子式C25H21N7O3
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 47 mg/mL
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SMILESO=C(C1=CC=C(N)N=C1)NC2=CC=CC(C3=NC(N4CCOCC4)=C(OC5=NC=CC=C56)C6=N3)=C2
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化学全称3-Pyridinecarboxamide, 6-amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Jefferies HB, et al. EMBO Rep. 2008 Feb;9(2):164-70.
2. Osborne SL, et al. J Biol Chem. 2008 Feb 1;283(5):2804-13.
3. Ikonomov OC, et al. Biochem Biophys Res Commun. 2009 May 8;382(3):566-70.
4. Kerr MC, et al. EMBO J. 2010 Apr 21;29(8):1331-47.
