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AS2795440
CAS No. ——
AS2795440 ( AS 2795440 | AS-2795440 )
产品货号. M17015 CAS No. ——
一种新型有效、选择性、口服 PIKfyve 抑制剂，可选择性降低 c-Rel 与 IL-12p40 和 IL-1β 基因启动子的结合。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称AS2795440
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述一种新型有效、选择性、口服 PIKfyve 抑制剂，可选择性降低 c-Rel 与 IL-12p40 和 IL-1β 基因启动子的结合。
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产品描述A novel potent, selective, oral PIKfyve inhibitor that selectively decreases c-Rel binding to gene promoters of IL-12p40 and IL-1β, regulates cytokine production through PIKfyve-c-Rel pathway ( IL-12p40 IC50=2 nM); inhibits the production of IL-12p40, IL-6 and IL-1β but not TNFα in activated macrophages or dendritic cells, and expression of IgM-induced MHC class II on B cells; reduces Akt phosphorylation in IFNγ/LPS-stimulated RAW264.7 cells, greatly increases cell size with many small vesicles in the cytoplasm; prevents the development of arthritis in rats.
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体外实验——
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体内实验——
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同义词AS 2795440 | AS-2795440
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通路PI3K/Akt/mTOR signaling
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靶点PIKfyve
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受体PIKfyve
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研究领域——
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适应症——
化学信息
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CAS Number——
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分子量494.643
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分子式C30H34N6O
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称N-(6'-(1-isopropylpiperidin-4-yl)-6-methyl-[3,3'-bipyridin]-5-yl)-2,3-dimethyl-1H-pyrrolo[3,2-b]pyridine-5-carboxamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Terajima M, et al. Eur J Pharmacol. 2016 Jun 5;780:93-105.
