WY-135 ( WY135 )

产品货号. M13452 CAS No. 2163060-83-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

拼团产品询价大包装询价加入购物车

产品名称

WY-135
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

WY-135 (WY135) is a novel potent inhibitor of ALK and ROS1 with IC50 of 1.2 and 0.48 nM, respectively.
产品描述

WY-135 (WY135) is a novel potent inhibitor of ALK and ROS1 with IC50 of 1.2 and 0.48 nM, respectively; exhibits better enzyme inhibitory activity than ceritinib, demonstrates anti-proliferative effects on Karpas299 and H2228 cells with IC50 of 28 and 164 nM respectively in MTT assay; induces cell cycle arrest at G1 phase in a dose-dependent manner and subsequently progressed into apoptosis, significantly suppressed ALK and its downstream protein expression.
同义词

WY135
通路

Angiogenesis
靶点

ALK
受体

ALK
研究领域

——
适应症

——

CAS Number

2163060-83-9
分子量

612.15
分子式

C28H34ClN9O3S
纯度

>98% (HPLC)
溶解度

——
SMILES

CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4C=C(N=N4)CN5CCN(CC5)C)OC
化学全称

5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-((4-methylpiperazin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)phenyl)pyrimidine-2,4-diamine

1. Han M, et al. Chem Biol Interact. 2018 Mar 25;284:24-31.
2. Wang Y, et al. Eur J Med Chem. 2018 Jan 1;143:123-136.

计算器

产品手册

关联产品

CEP-28122

A highly potent and selective, orally active ALK inhibitor with IC50 of 1.9 nM.
KRCA-0008

KRCA-0008 is a potent, selective ALK inhibitor with IC50 of 12 nM (wt ALK).
SM 16

SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).