LDK378 ( Ceritinib )

产品货号. M10160 CAS No. 1032900-25-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

LDK378
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Ceritinib is an orally available inhibitor of the receptor tyrosine kinase activity of anaplastic lymphoma kinase (ALK) with antineoplastic activity.
产品描述

Ceritinib is an orally available inhibitor of the receptor tyrosine kinase activity of anaplastic lymphoma kinase (ALK) with antineoplastic activity. Upon administration, ceritinib binds to and inhibits wild-type ALK kinase, ALK fusion proteins and ALK point mutation variants. Inhibition of ALK leads to both the disruption of ALK-mediated signaling and the inhibition of cell growth in ALK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a variety of tumor cell types.
同义词

Ceritinib
通路

Angiogenesis
靶点

ALK
受体

ALK; FLT3; IGF-1R; Insulin Receptor; STK22D
研究领域

Cancer
适应症

——

CAS Number

1032900-25-6
分子量

558.14
分子式

C28H36ClN5O3S
纯度

>98%(HPLC)
溶解度

Ethanol: 3 mg/mL (5.37 mM); DMSO: 20 mg/mL warmed (35.83 mM)
SMILES

CC(C)OC1=C(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)C=C(C)C(=C1)C1CCNCC1
化学全称

——

1. Marsilje TH, et al. J Med Chem. 2013, Jun 6.

计算器

产品手册

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