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CPI-169
CAS No. 1450655-76-1
CPI-169 ( CPI-169; CPI 169; CPI169 )
产品货号. M17305 CAS No. 1450655-76-1
CPI-169 is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively.
纯度: 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥583 | 有现货 |
|
| 5MG | ￥1029 | 有现货 |
|
| 10MG | ￥1458 | 有现货 |
|
| 25MG | ￥3208 | 有现货 |
|
| 50MG | ￥4771 | 有现货 |
|
| 100MG | ￥6796 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称CPI-169
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述CPI-169 is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively.
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产品描述CPI-169 is a potent inhibitor of enhancer of zeste homolog 2 (EZH2) with an IC50 value of <1nM for polycomb repressive complex 2 (PRC2). CPI-169 was shown to inhibit tumor growth in a NHL xenograft model, reducing global H3K27me3.1 It has also been shown to synergize with the B-cell lymphoma inhibitor, ABT-199, to suppress the growth of NHL cell lines.
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同义词CPI-169; CPI 169; CPI169
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通路Angiogenesis
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靶点ALK
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受体EZH1; EZH2 WT; EZH2 Y641N
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研究领域Cancer
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适应症——
化学信息
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CAS Number1450655-76-1
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分子量528.66
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分子式C27H36N4O5S
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纯度98%
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溶解度DMSO : ≥ 59 mg/mL. 111.60 mM
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SMILESCCS(=O)(=O)N1CCC(CC1)C(C)n1c2ccccc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C
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化学全称(R,Z)-1-(1-(1-(ethylsulfonyl)piperidin-4-yl)ethyl)-N-((2-hydroxy-4-methoxy-6-methylpyridin-3-yl)methyl)-2-methyl-1H-indole-3-carbimidic acid
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Bradley WD,etal.EZH2 inhibitor efficacy in non-Hodgkin's lymphoma does not require suppression of H3K27 monomethylation.Chem Biol. 2014 Nov 20;21(11):1463-75.
产品手册
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CPI-169
CPI-169 is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively.
