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Alectinib
CAS No. 1256580-46-7
Alectinib ( CH5424802;AF-802;CH 5424802;AF802;AF 802 )
产品货号. M11051 CAS No. 1256580-46-7
A potent, selective ALK inhibitor with IC50 of 1.9 nM; shows high selectivity versus KDR, KIT and MET (IC50>1,400 nM).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥316 | 有现货 |
|
| 5MG | ￥510 | 有现货 |
|
| 10MG | ￥640 | 有现货 |
|
| 50MG | ￥867 | 有现货 |
|
| 100MG | ￥1385 | 有现货 |
|
| 200MG | ￥2211 | 有现货 |
|
| 500MG | ￥3718 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Alectinib
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A potent, selective ALK inhibitor with IC50 of 1.9 nM; shows high selectivity versus KDR, KIT and MET (IC50>1,400 nM).
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产品描述A potent, selective ALK inhibitor with IC50 of 1.9 nM; shows high selectivity versus KDR, KIT and MET (IC50>1,400 nM); exhibits anti-proliferative activity against NPM-ALK-positive cellline KARPAS-299 with IC50 of 3 nM; also inhibits mutant ALK F1174L and R1275Q with IC50 of 1 nM and 3.5 nM respectively; orally active.Lung Cancer Approved
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同义词CH5424802;AF-802;CH 5424802;AF802;AF 802
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通路Angiogenesis
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靶点ALK
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受体ALK;ALK(F1174L);ALK(R1275Q);INSR;VEGFR2(KDR)
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研究领域Cancer
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适应症Lung Cancer
化学信息
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CAS Number1256580-46-7
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分子量482.62
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分子式C30H34N4O2
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纯度>98% (HPLC)
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溶解度DMSO: 6.2 mg/mL (Need warming)
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SMILESCCC1=C(C=C2C(=C1)C(=O)C1=C(NC3=C1C=CC(=C3)C#N)C2(C)C)N1CCC(CC1)N1CCOCC1
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化学全称5H-Benzo[b]carbazole-3-carbonitrile, 9-ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Kinoshita K, et al. Bioorg Med Chem. 2012 Feb 1;20(3):1271-80.
2. Sakamoto H, et al. Cancer Cell. 2011 May 17;19(5):679-90.
3. Kodama T, et al. Mol Cancer Ther. 2014 Dec;13(12):2910-8.
2. Sakamoto H, et al. Cancer Cell. 2011 May 17;19(5):679-90.
3. Kodama T, et al. Mol Cancer Ther. 2014 Dec;13(12):2910-8.
产品手册
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