CEP-28122 ( CEP28122; CEP 28122; CEP28122 )

产品货号. M10107 CAS No. 1022958-60-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

CEP-28122
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A highly potent and selective, orally active ALK inhibitor with IC50 of 1.9 nM.
产品描述

A highly potent and selective, orally active ALK inhibitor with IC50 of 1.9 nM; exhibits no-to-weak inhibition against a panel of 259 kinases and only 15 kinases showes >90% inhibition at 1 uM; shows growth inhibition/cytotoxicity of ALCL, NSCLC, and neuroblastoma cells, and displays dose-dependent inhibition of ALK tyrosine phosphorylation in tumor xenografts in mice (30 mg/kg).
同义词

CEP28122; CEP 28122; CEP28122
通路

Angiogenesis
靶点

ALK
受体

ALK
研究领域

Cancer
适应症

——

CAS Number

1022958-60-6
分子量

539.07
分子式

C28H35ClN6O3
纯度

>98% (HPLC)
溶解度

10 mM in DMSO
SMILES

O=C([C@H]1[C@](C2)([H])C=C[C@]2([H])[C@H]1NC3=NC(NC4=CC=C5C(CC[C@@H](N6CCOCC6)CC5)=C4OC)=NC=C3Cl)N
化学全称

Bicyclo[2.2.1]hept-5-ene-2-carboxamide, 3-[[5-chloro-2-[[(7S)-6,7,8,9-tetrahydro-1-methoxy-7-(4-morpholinyl)-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-, (1S,2S,3R,4R)-

1. Cheng M, et al. Mol Cancer Ther. 2012 Mar;11(3):670-9.
2. Sullivan I, et al. Ther Adv Med Oncol. 2016 Jan;8(1):32-47.

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