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CEP-28122

CAS No. 1022958-60-6

CEP-28122 ( CEP28122; CEP 28122; CEP28122 )

产品货号. M10107 CAS No. 1022958-60-6

A highly potent and selective, orally active ALK inhibitor with IC50 of 1.9 nM.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥608 有现货
5MG ¥1094 有现货
10MG ¥1774 有现货
25MG ¥3200 有现货
100MG 获取报价 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    CEP-28122
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    A highly potent and selective, orally active ALK inhibitor with IC50 of 1.9 nM.
  • 产品描述
    A highly potent and selective, orally active ALK inhibitor with IC50 of 1.9 nM; exhibits no-to-weak inhibition against a panel of 259 kinases and only 15 kinases showes >90% inhibition at 1 uM; shows growth inhibition/cytotoxicity of ALCL, NSCLC, and neuroblastoma cells, and displays dose-dependent inhibition of ALK tyrosine phosphorylation in tumor xenografts in mice (30 mg/kg).
  • 同义词
    CEP28122; CEP 28122; CEP28122
  • 通路
    Angiogenesis
  • 靶点
    ALK
  • 受体
    ALK
  • 研究领域
    Cancer
  • 适应症
    ——

化学信息

  • CAS Number
    1022958-60-6
  • 分子量
    539.07
  • 分子式
    C28H35ClN6O3
  • 纯度
    >98% (HPLC)
  • 溶解度
    10 mM in DMSO
  • SMILES
    O=C([C@H]1[C@](C2)([H])C=C[C@]2([H])[C@H]1NC3=NC(NC4=CC=C5C(CC[C@@H](N6CCOCC6)CC5)=C4OC)=NC=C3Cl)N
  • 化学全称
    Bicyclo[2.2.1]hept-5-ene-2-carboxamide, 3-[[5-chloro-2-[[(7S)-6,7,8,9-tetrahydro-1-methoxy-7-(4-morpholinyl)-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-, (1S,2S,3R,4R)-

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Cheng M, et al. Mol Cancer Ther. 2012 Mar;11(3):670-9.
2. Sullivan I, et al. Ther Adv Med Oncol. 2016 Jan;8(1):32-47.
产品手册
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