WAY-204688
CAS No. 796854-35-8
WAY-204688 ( SIM-688; SIM688 )
产品货号. M26862 CAS No. 796854-35-8
WAY-204688 is a selective and orally active estrogen receptor inhibitor of NF-κB transcriptional activity (IC50 = 122 nM in HAECT-1 cells).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥6658 | 有现货 |
|
10MG | ¥9153 | 有现货 |
|
25MG | ¥13689 | 有现货 |
|
50MG | ¥18549 | 有现货 |
|
100MG | 获取报价 | 有现货 |
|
200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称WAY-204688
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述WAY-204688 is a selective and orally active estrogen receptor inhibitor of NF-κB transcriptional activity (IC50 = 122 nM in HAECT-1 cells).
-
产品描述WAY-204688 is a selective and orally active estrogen receptor inhibitor of NF-κB transcriptional activity (IC50 = 122 nM in HAECT-1 cells).(In Vitro):WAY-204688 displaces [3H]E2 from the ERα ligand-binding domain protein (C50=2.43 μM) and from the ERβ ligand-binding domain protein (IC50=1.5 μM).(In Vivo):WAY-204688 (5 mg/kg per day, p.o.) inhibits pro-inflammatory genes including MHI, VCAM-1, RANTES, and TNF-α and induces the gene products and uterine wet weight. WAY-204688 (0.3 mg/kg, p.o.) is active in the Lewis rat adjuvant-induced arthritis model .
-
同义词SIM-688; SIM688
-
通路Endocrinology/Hormones
-
靶点Estrogen Receptor/ERR
-
受体Fungal
-
研究领域——
-
适应症——
化学信息
-
CAS Number796854-35-8
-
分子量556.6
-
分子式C34H31F3N2O2
-
纯度>98% (HPLC)
-
溶解度——
-
SMILES[C@H]([C@](C(=O)N1CCC(CC1)C2=CC(C(F)(F)F)=CC=C2)(C#N)C)(C=3C4=C(C=CC3)C=CC=C4)C5=C(OC)C=CC=C5
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Hajime Iwamura, et al. Antifungal Activity of Substituted 7-(β-D-Ribofuranosyl)pyrrolo-[2,3-d]pyrimidines. Agricultural and Biological Chemistry, Volume 40, Issue 7, 1 July 1976, Pages
产品手册
关联产品
-
4',7-Dimethoxyisofla...
4', 7-dimethoxyisoflavone, a kind of isoflavonoids, showed inhibitory effects on rat prostate testosterone 5α-reductase.
-
Pimaricin
Natamycin is a Polyene Antimicrobial.
-
Prochloraz
Prochloraz is a broad-spectrum contact imidazole fungicide. Prochloraz inhibits human placental microsomal aromatase in vitro (IC50 = 40 nM).