CH5183284
CAS No. 1265229-25-1
CH5183284 ( Debio-1347; Debio 1347; Debio1347; CH5183284 )
产品货号. M17232 CAS No. 1265229-25-1
CH5183284 is a selective and orally available FGFR inhibitor, which is for FGFR1(IC50=9.3 nM), FGFR2(IC50=7.6 nM), FGFR3(IC50=290), and FGFR4(IC50=22 nM), respectively.
纯度: 95%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥316 | 有现货 |
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10MG | ¥583 | 有现货 |
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25MG | ¥1021 | 有现货 |
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50MG | ¥1604 | 有现货 |
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100MG | ¥2989 | 有现货 |
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200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称CH5183284
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述CH5183284 is a selective and orally available FGFR inhibitor, which is for FGFR1(IC50=9.3 nM), FGFR2(IC50=7.6 nM), FGFR3(IC50=290), and FGFR4(IC50=22 nM), respectively.
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产品描述Debio-1347, also known as FF284 and CH5183284, is an orally bioavailable inhibitor of the fibroblast growth factor receptor subtypes 1 (FGFR-1), 2 (FGFR-2) and 3 (FGFR-3), with potential antineoplastic activity. FGFR inhibitor debio 1347 binds to and inhibits FGFR-1, -2, and -3, which result in the inhibition of FGFR-mediated signal transduction pathways. This leads to the inhibition of both tumor cell proliferation and angiogenesis, and causes cell death in FGFR-overexpressing tumor cells.
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同义词Debio-1347; Debio 1347; Debio1347; CH5183284
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通路Endocrinology/Hormones
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靶点Estrogen Receptor/ERR
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受体FGFR1; FGFR2; FGFR3; FGFR4
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研究领域Cancer
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适应症——
化学信息
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CAS Number1265229-25-1
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分子量356.38
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分子式C20H16N6O
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纯度95%
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溶解度DMSO : 25 mg/mL. 70.15 mM;
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SMILESCc1nc2c([nH]1)cc(cc2)n1c(c(cn1)C(=O)c1cc2ccccc2[nH]1)N
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化学全称(5-amino-1-(2-methyl-1H-benzo[d]imidazol-6-yl)-1H-pyrazol-4-yl)(1H-indol-2-yl)methanone
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Nakanishi Y, et al. Mol Y Ther. 2014, 13(11), 2547-2558.
产品手册
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