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CH5183284

CAS No. 1265229-25-1

CH5183284 ( Debio-1347; Debio 1347; Debio1347; CH5183284 )

产品货号. M17232 CAS No. 1265229-25-1

CH5183284 is a selective and orally available FGFR inhibitor, which is for FGFR1(IC50=9.3 nM), FGFR2(IC50=7.6 nM), FGFR3(IC50=290), and FGFR4(IC50=22 nM), respectively.

纯度: 95%

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥316 有现货
10MG ¥583 有现货
25MG ¥1021 有现货
50MG ¥1604 有现货
100MG ¥2989 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    CH5183284
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    CH5183284 is a selective and orally available FGFR inhibitor, which is for FGFR1(IC50=9.3 nM), FGFR2(IC50=7.6 nM), FGFR3(IC50=290), and FGFR4(IC50=22 nM), respectively.
  • 产品描述
    Debio-1347, also known as FF284 and CH5183284, is an orally bioavailable inhibitor of the fibroblast growth factor receptor subtypes 1 (FGFR-1), 2 (FGFR-2) and 3 (FGFR-3), with potential antineoplastic activity. FGFR inhibitor debio 1347 binds to and inhibits FGFR-1, -2, and -3, which result in the inhibition of FGFR-mediated signal transduction pathways. This leads to the inhibition of both tumor cell proliferation and angiogenesis, and causes cell death in FGFR-overexpressing tumor cells.
  • 同义词
    Debio-1347; Debio 1347; Debio1347; CH5183284
  • 通路
    Endocrinology/Hormones
  • 靶点
    Estrogen Receptor/ERR
  • 受体
    FGFR1; FGFR2; FGFR3; FGFR4
  • 研究领域
    Cancer
  • 适应症
    ——

化学信息

  • CAS Number
    1265229-25-1
  • 分子量
    356.38
  • 分子式
    C20H16N6O
  • 纯度
    95%
  • 溶解度
    DMSO : 25 mg/mL. 70.15 mM;
  • SMILES
    Cc1nc2c([nH]1)cc(cc2)n1c(c(cn1)C(=O)c1cc2ccccc2[nH]1)N
  • 化学全称
    (5-amino-1-(2-methyl-1H-benzo[d]imidazol-6-yl)-1H-pyrazol-4-yl)(1H-indol-2-yl)methanone

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Nakanishi Y, et al. Mol Y Ther. 2014, 13(11), 2547-2558.
产品手册
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