Vaniprevir
CAS No. 923590-37-8
Vaniprevir ( MK-7009;MK7009;MK 7009 )
产品货号. M16617 CAS No. 923590-37-8
A potent, selective, orally available inhibitor of HCV NS3/4A protease with Ki of 0.05 and 0.9 nM for GT1b and 2a protease, respectively.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥9477 | 有现货 |
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50MG | ¥19278 | 有现货 |
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100MG | ¥25110 | 有现货 |
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200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Vaniprevir
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述A potent, selective, orally available inhibitor of HCV NS3/4A protease with Ki of 0.05 and 0.9 nM for GT1b and 2a protease, respectively.
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产品描述A potent, selective, orally available inhibitor of HCV NS3/4A protease with Ki of 0.05 and 0.9 nM for GT1b and 2a protease, respectively; displays excellent selectivity against both a range of human proteases and a broad panel of pharmacologically relevant targets; has replicon EC50 of 3 and 9 nM for GT1b and 2a, respectively, has good plasma exposure and excellent liver exposure in multiple species.HCV Infection Approved
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同义词MK-7009;MK7009;MK 7009
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通路Microbiology/Virology
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靶点HCV
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受体HCV
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研究领域Infection
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适应症HCV Infection
化学信息
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CAS Number923590-37-8
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分子量757.94
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分子式C38H55N5O9S
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESCC[C@@H]1C[C@@]1(C(NS(=O)(C2CC2)=O)=O)NC([C@@H]3C[C@@H]4CN3C([C@H](C(C)(C)C)NC(OCC(C)(CCCCC5=CC=CC6=C5CN(C(O4)=O)C6)C)=O)=O)=O
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化学全称Cyclopropanecarboxamide, N-[[[6-(2-carboxy-2,3-dihydro-1H-isoindol-4-yl)-2,2-dimethylhexyl]oxy]carbonyl]-3-methyl-L-valyl-(4R)-4-hydroxy-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethyl-, (12)-lactone, (1R,2R)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. McCauley JA, et al. J Med Chem. 2010 Mar 25;53(6):2443-63.
2. Liverton NJ, et al. Antimicrob Agents Chemother. 2010 Jan;54(1):305-11.
3. Manns MP, et al. Hepatology. 2012 Sep;56(3):884-93.
2. Liverton NJ, et al. Antimicrob Agents Chemother. 2010 Jan;54(1):305-11.
3. Manns MP, et al. Hepatology. 2012 Sep;56(3):884-93.
产品手册
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