Valinomycin ( NSC 122023 )

产品货号. M29573 CAS No. 2001-95-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Valinomycin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Valinomycin is a cyclic depsipeptide antibiotic and a potassium-specific ionophore.Valinomycin induces PINK1 activation and promotes Parkin phosphorylation at Ser65.
产品描述

Valinomycin is a cyclic depsipeptide antibiotic and a potassium-specific ionophore.Valinomycin induces PINK1 activation and promotes Parkin phosphorylation at Ser65.(In Vitro):Valinomycin significantly induced CHO cell death within 12 hours after administration. In CHO cells treated with valinomycin, within the first few hours, multiple apoptotic features were observed, including caspase-3 activation, phosphatidylserine (PS) membrane translocation, and mitochondrial membrane depolarization. Increasing the extracellular potassium concentration can reduce potassium efflux .(In Vivo):Valinomycin is irritating in contact with eyes and skin. Inhalation of Valinomycin can cause respiratory disturbances and even loss of consciousness. The median lethal dose (LD50) of Valinomycin in mice and rabbits was 2.5 mg/kg and 5 mg/kg, respectively. Valinomycin also has various chronic effects, including central and peripheral nervous system damage, eye damage, lens damage, and corneal damage .
同义词

NSC 122023
通路

Apoptosis
靶点

Apoptosis
受体

Apoptosis
研究领域

——
适应症

——

CAS Number

2001-95-8
分子量

1111.3
分子式

C54H90N6O18
纯度

>98% (HPLC)
溶解度

——
SMILES

CC(C)[C@H](C(O[C@@H](C)C(N[C@@H](C(C)C)C(O[C@H](C(C)C)C(N[C@H](C(C)C)C(O[C@@H](C)C(N[C@@H](C(C)C)C(O[C@H](C(C)C)C(N[C@H](C(C)C)C(O[C@@H](C)C(N[C@@H](C(C)C)C(O[C@@H]1C(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC1=O
化学全称

——

计算器

产品手册

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