UNC2250

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

UNC2250 是一种有效的选择性 Mer 抑制剂，IC50 为 1.7 nM，选择性比密切相关的激酶 Axl/Tyro3 约 160 倍和 60 倍。

UNC2250 is a potent and selective Mer inhibitor with IC50 of 1.7 nM, about 160- and 60-fold selectivity over the closely related kinases Axl/Tyro3.

UNC2250 (5-500 nM; 1 hour) inhibits Mer phosphorylation in 697 B-ALL cells with an IC50 value of 9.8 nM.UNC2250 efficiently inhibits ligand-dependent phosphorylation of a chimeric protein consisting of the extracellular and transmembrane domains of the epidermal growth factor (EGF) receptor and the intracellular tyrosine kinase domain of Mer.UNC2250 incubation inhibits colony formation in soft agar cultures of the BT-12 rhabdoid tumor and the Colo699 NSCLC cell lines . Western Blot Analysis Cell Line:697 B-ALL cells Concentration:5, 10, 20, 50, 100, 250, 500 nMIncubation Time:1 hour Result:Inhibits Mer phosphorylation in 697 B-ALL cells with an IC50 value of 9.8 nM.

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UNC2250, UNC-2250, UNC 2250

Tyrosine Kinase

TAM Receptor

AXL| Mer| Tyro3

Cancer

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1493694-70-4

440.58

C24H36N6O2

>98% (HPLC)

DMSO: 2 mg/mL warmed (4.53 mM)

O[C@H]1CC[C@H](NC2=NC(NCCCC)=NC=C2C3=NC=C(CN4CCOCC4)C=C3)CC1

(1r,4r)-4-((2-(butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol

(-20℃)

With Ice Pack

≥ 2 years