ULK-100 ( ULK100 )

产品货号. M16933 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

拼团产品询价大包装询价加入购物车

产品名称

ULK-100
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

ULK-100 (ULK100) is a potent and selective ULK1 inhibitor with in vitro IC50 of 1.6 nM, inhibits ULK2 with IC50 of 2.6 nM.
产品描述

ULK-100 (ULK100) is a potent and selective ULK1 inhibitor with in vitro IC50 of 1.6 nM, inhibits ULK2 with IC50 of 2.6 nM; reduces Ser15 phosphorylation in a concentration-dependent manner in cell-based assay (EC50=83 nM), which is more potent than SBI-0206965 showing a cellular EC50 of 2.4 uM; displays desirable kinome selectivity profile.
同义词

ULK100
通路

Autophagy
靶点

ULK
受体

ULK
研究领域

——
适应症

——

CAS Number

——
分子量

599.72
分子式

C31H36F3N5O2S
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C(C1=CC(C2=C3N=CC(OCCN4CCCCC4)=CN3N=C2)=CS1)N[C@@H](C(C)C)C(F)(F)F
化学全称

(S)-N-(3-ethyl-1,1,1-trifluoropentan-2-yl)-4-(6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)thiophene-2-carboxamide

1. Martin KR, et al. iScience. 2018 Oct 26;8:74-84. doi: 10.1016/j.isci.2018.09.012.

计算器

产品手册

关联产品

SBI-0206965

SBI-0206965 (SBI 0206965) is a potent and specific small molecule ULK1 kinase inhibitor with IC50 of 108 nM.
LYN-1604

LYN-1604 is a potential ULK1 agonist (enzymatic activity=195.7% at 100 nM and IC50=1.66 uM against MDA-MB-231 cells).
MRT67307

MRT67307 is a potent, dual inhibitor of IKKε and TBK-1 with IC50 of 160 and 19 nM at 0.1 mM ATP in vitro, also potently inhibit ULK1 and ULK2 in vitro (IC50=45 and 38 nM) and block autophagy in cells.