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ULK-100
CAS No. ——
ULK-100 ( ULK100 )
产品货号. M16933 CAS No. ——
ULK-100 (ULK100) is a potent and selective ULK1 inhibitor with in vitro IC50 of 1.6 nM, inhibits ULK2 with IC50 of 2.6 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称ULK-100
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述ULK-100 (ULK100) is a potent and selective ULK1 inhibitor with in vitro IC50 of 1.6 nM, inhibits ULK2 with IC50 of 2.6 nM.
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产品描述ULK-100 (ULK100) is a potent and selective ULK1 inhibitor with in vitro IC50 of 1.6 nM, inhibits ULK2 with IC50 of 2.6 nM; reduces Ser15 phosphorylation in a concentration-dependent manner in cell-based assay (EC50=83 nM), which is more potent than SBI-0206965 showing a cellular EC50 of 2.4 uM; displays desirable kinome selectivity profile.
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同义词ULK100
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通路Autophagy
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靶点ULK
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受体ULK
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研究领域——
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适应症——
化学信息
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CAS Number——
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分子量599.72
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分子式C31H36F3N5O2S
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(C1=CC(C2=C3N=CC(OCCN4CCCCC4)=CN3N=C2)=CS1)N[C@@H](C(C)C)C(F)(F)F
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化学全称(S)-N-(3-ethyl-1,1,1-trifluoropentan-2-yl)-4-(6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)thiophene-2-carboxamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Martin KR, et al. iScience. 2018 Oct 26;8:74-84. doi: 10.1016/j.isci.2018.09.012.
产品手册
关联产品
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ULK-101
ULK-101 (ULK101) is a potent and selective ULK1 inhibitor with in vitro IC50 of 8.3 nM, inhibits ULK2 with IC50 of 30 nM.
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MRT-68921
A potent, relatively specific inhibitor of both ULK1 and ULK2 with IC50 of 2.9 and 1.1 nM, respectively.
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ULK1-IN-1
ULK1-IN-1 highly potent ULK1 inhibitor with IC50 of 8 nM, with no enough selectivity but sufficient potency, a cellular probe of autophagy.
