BL-918 ( BL918 )

产品货号. M13336 CAS No. 2101517-69-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

BL-918
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

BL-918 is a small molecule activator of ULK1 with EC50 of 24 nM (243% kinase activity at 100 nM).
产品描述

BL-918 is a small molecule activator of ULK1 with EC50 of 24 nM (243% kinase activity at 100 nM), induces autophagy via the ULK complex in SH-SY5Y cells; displays a cytoprotective effect on MPP+-treated SH-SY5Y cells, as well as protected against MPTP-induced motor dysfunction and loss of dopaminergic neurons by targeting ULK1-modulated autophagy in mouse models of PD.
同义词

BL918
通路

Autophagy
靶点

ULK
受体

ULK
研究领域

——
适应症

——

CAS Number

2101517-69-3
分子量

533.44
分子式

C23H15F8N3OS
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C(NC1=CC=C(F)C=C1F)[C@H](NC(NC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=S)C3=CC=CC=C3
化学全称

(R)-2-(3-(3,5-Bis(trifluoromethyl)phenyl)thioureido)-N-(2,4-difluorophenyl)-2-phenylacetamide

1. Ouyang L, et al. J Med Chem. 2018 Apr 12;61(7):2776-2792.

计算器

产品手册

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BL-918

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