SBI-0206965 ( SBI 0206965;SBI0206965 )

产品货号. M12941 CAS No. 1884220-36-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

SBI-0206965
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

SBI-0206965 (SBI 0206965) is a potent and specific small molecule ULK1 kinase inhibitor with IC50 of 108 nM.
产品描述

SBI-0206965 (SBI 0206965) is a potent and specific small molecule ULK1 kinase inhibitor with IC50 of 108 nM; displays 7-fold less potency for ULK2 (IC50=711 nM); inhibits Beclin1 Ser15 and Vps34 Ser249 phosphorylation to comparable extents in HEK-293T cells; suppresses autophagy induced by mTOR inhibition and prevents ULK1-dependent cell survival; greatly synergized with mTOR inhibitors to kill tumor cells.
同义词

SBI 0206965;SBI0206965
通路

Autophagy
靶点

ULK
受体

ULK1
研究领域

Cancer
适应症

——

CAS Number

1884220-36-3
分子量

489.32
分子式

C21H21BrN4O5
纯度

>98% (HPLC)
溶解度

10 mM in DMSO
SMILES

O=C(NC)C1=CC=CC=C1OC2=NC(NC3=CC(OC)=C(OC)C(OC)=C3)=NC=C2Br
化学全称

2-((5-bromo-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)oxy)-N-methylbenzamide

1. Egan DF, et al. Mol Cell. 2015 Jul 16;59(2):285-97.

计算器

产品手册

关联产品

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BL-918 is a small molecule activator of ULK1 with EC50 of 24 nM (243% kinase activity at 100 nM).
ULK-100

ULK-100 (ULK100) is a potent and selective ULK1 inhibitor with in vitro IC50 of 1.6 nM, inhibits ULK2 with IC50 of 2.6 nM.
MRT-68921

A potent, relatively specific inhibitor of both ULK1 and ULK2 with IC50 of 2.9 and 1.1 nM, respectively.