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UC-112
CAS No. 383392-66-3
UC-112 ( UC112 )
产品货号. M14330 CAS No. 383392-66-3
UC-112是一种新型IAP抑制剂，可有效抑制人黑色素瘤（A375和M14）和人前列腺（PC-3和DU145）癌细胞系，IC50为0.7-3.4 uM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥551 | 有现货 |
|
| 5MG | ￥915 | 有现货 |
|
| 10MG | ￥1442 | 有现货 |
|
| 25MG | ￥3038 | 有现货 |
|
| 50MG | ￥4674 | 有现货 |
|
| 100MG | ￥6691 | 有现货 |
|
| 500MG | ￥13608 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称UC-112
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述UC-112是一种新型IAP抑制剂，可有效抑制人黑色素瘤（A375和M14）和人前列腺（PC-3和DU145）癌细胞系，IC50为0.7-3.4 uM。
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产品描述UC-112 is a novel IAP inhibitor that potently inhibits human melanoma (A375 and M14) and human prostate (PC-3 and DU145) cancer cell lines with IC50 of 0.7-3.4 uM; also potently inhibits the growth of P-gp-overexpressed multidrug-resistant cancer cells, strongly activates caspase-3/7 and caspase-9 activities, and selectively downregulates survivin level at 1 uM; strongly inhibits tumor growth and reduces both X chromosome-linked IAP and survivin levels in an A375 human melanoma xenograft model in vivo.
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体外实验——
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体内实验——
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同义词UC112
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通路Apoptosis
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靶点IAP
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受体IAP
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研究领域Cancer
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适应症——
化学信息
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CAS Number383392-66-3
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分子量348.4382
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分子式C22H24N2O2
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESOC1=C2N=CC=CC2=C(COCC3=CC=CC=C3)C=C1CN4CCCC4
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化学全称8-Quinolinol, 5-[(phenylmethoxy)methyl]-7-(1-pyrrolidinylmethyl)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Wang J, et al. J Pharmacol Exp Ther. 2014 May;349(2):319-29.
2. Xiao M, et al. PLoS One. 2015 Jun 12;10(6):e0129807.
