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Embelin
CAS No. 550-24-3
Embelin ( Embelic acid | Emberine | NSC-91874 )
产品货号. M14989 CAS No. 550-24-3
Embelin (Embelic Acid, Emberine, NSC-91874) 是一种细胞渗透性苯醌化合物，具有抗肿瘤特性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 10MG | ￥405 | 有现货 |
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| 25MG | ￥689 | 有现货 |
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| 50MG | ￥1296 | 有现货 |
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| 100MG | ￥2543 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Embelin
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Embelin (Embelic Acid, Emberine, NSC-91874) 是一种细胞渗透性苯醌化合物，具有抗肿瘤特性。
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产品描述Embelin (Embelic acid, Emberine, NSC-91874) is a cell-permeable benzoquinone compound that exhibits antitumor properties; specifically antagonizes XIAP-mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3 (IC50=4.1 uM); has anti-inflammatory activities in both acute and chronic irritant contact dermatitis in vivo; also inhibits plasminogen activator inhibitor-1 (PAI-1) with IC50 of 1.62 uM.(In Vitro):Embelin (Embelic acid) has a minimal effect on normal prostate epithelial and fibroblast cells with low levels of XIAP.
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体外实验——
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体内实验——
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同义词Embelic acid | Emberine | NSC-91874
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通路Apoptosis
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靶点IAP
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受体5-Lipoxygenase|mPGES-1|XIAP
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研究领域Cancer
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适应症——
化学信息
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CAS Number550-24-3
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分子量294.3859
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分子式C17H26O4
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESCCCCCCCCCCCC1=C(C(=O)C=C(C1=O)O)O
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化学全称2,5-Cyclohexadiene-1,4-dione, 2,5-dihydroxy-3-undecyl-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Siegel C, et al. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11662-7.
2. Kalyan Kumar G, et al. Eur J Pharmacol. 2011 Jul 15;662(1-3):63-9.
3. Lin Z, et al. Chem Biol. 2013 Feb 21;20(2):253-61.
