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Triparanol
CAS No. 78-41-1
Triparanol ( NSC 65345; NSC-65345; NSC65345 )
产品货号. M27836 CAS No. 78-41-1
Triparanol interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1, leading to down-regulation of Hedgehog signaling.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥9153 | 有现货 |
|
| 10MG | ￥12312 | 有现货 |
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| 25MG | ￥18306 | 有现货 |
|
| 50MG | ￥24219 | 有现货 |
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| 100MG | ￥33372 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Triparanol
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Triparanol interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1, leading to down-regulation of Hedgehog signaling.
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产品描述Triparanol interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1, leading to down-regulation of Hedgehog signaling. Triparanol suppresses human tumor growth and is an antilipemic agent with high ophthalmic toxicity.(In Vitro):Triparanol is an effective cholesterol biosynthesis inhibitor blocking the 24-dehydrocholesterol reductase. Triparanol can block proliferation and induce apoptosis in multiple human cancer cells including lung, breast, liver, pancreatic, prostate cancer, and melanoma cells, and growth inhibition can be rescued by the exogenous addition of cholesterol.
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同义词NSC 65345; NSC-65345; NSC65345
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通路Apoptosis
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靶点Apoptosis
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受体A2A/A1
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研究领域——
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适应症——
化学信息
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CAS Number78-41-1
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分子量438.0
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分子式C27H32ClNO2
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纯度>98% (HPLC)
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溶解度——
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SMILESCCN(CC)CCOc1ccc(cc1)C(O)(Cc1ccc(Cl)cc1)c1ccc(C)cc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Gillespie RJ, et al. Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines. Bioorg Med Chem Lett. 2008 May 1;18(9):2924-9.
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