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Tivozanib
CAS No. 475108-18-0
Tivozanib ( AV-951;AV951;AV 951 )
产品货号. M14578 CAS No. 475108-18-0
A highly potent inhibitor of pan-VEGFR with IC50s of 60/6.5/15 nM for VEGFR1/2/3.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥275 | 有现货 |
|
| 5MG | ￥446 | 有现货 |
|
| 10MG | ￥616 | 有现货 |
|
| 25MG | ￥1175 | 有现货 |
|
| 50MG | ￥2041 | 有现货 |
|
| 100MG | ￥3645 | 有现货 |
|
| 200MG | ￥5370 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Tivozanib
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A highly potent inhibitor of pan-VEGFR with IC50s of 60/6.5/15 nM for VEGFR1/2/3.
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产品描述A highly potent inhibitor of pan-VEGFR with IC50s of 60/6.5/15 nM for VEGFR1/2/3; also inhibits EphB2, PDGFR-α, PDGFR-β, c-Kit, and Tie2 (IC50=20-80 nM); inhibits VEGF-induced VEGFR-2 phosphorylation in endothelial cells (IC50=0.16 nM); p.o. active.Kidney Cancer Approved
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同义词AV-951;AV951;AV 951
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通路Angiogenesis
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靶点VEGFR
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受体EphB2;PDGFRα;VEGFR1;VEGFR2;VEGFR3
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研究领域Cancer
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适应症Kidney Cancer
化学信息
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CAS Number475108-18-0
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分子量454.86
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分子式C22H19ClN4O5
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESO=C(NC1=NOC(C)=C1)NC2=CC=C(OC3=CC=NC4=CC(OC)=C(OC)C=C34)C=C2Cl
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化学全称Urea, N-[2-chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Nakamura K, et al. Cancer Res. 2006 Sep 15;66(18):9134-42.
2. Eskens FA, et al. Clin Cancer Res. 2011 Nov 15;17(22):7156-63.
3. Momeny M, et al. Sci Rep. 2017 Apr 6;7:45954.
2. Eskens FA, et al. Clin Cancer Res. 2011 Nov 15;17(22):7156-63.
3. Momeny M, et al. Sci Rep. 2017 Apr 6;7:45954.
产品手册
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