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首页- Products - Angiogenesis - VEGFR - Pazopanib

Pazopanib

CAS No. 444731-52-6

Pazopanib ( GW-786034B;GW-786034;GW786034 )

产品货号. M14522 CAS No. 444731-52-6

A potent, orally available, pan-VEGFR inhibitor with IC50 of 10, 30, and 47 nM for VEGFR-1, -2, and -3, respectively.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
10MG ￥340 有现货
25MG ￥543 有现货
50MG ￥786 有现货
100MG ￥1199 有现货
200MG ￥2017 有现货
500MG ￥2827 有现货
1G 获取报价 有现货
拼团 产品询价 大包装询价 加入购物车

生物学信息

  • 产品名称
    Pazopanib
  • 注意事项
    本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
  • 产品简述
    A potent, orally available, pan-VEGFR inhibitor with IC50 of 10, 30, and 47 nM for VEGFR-1, -2, and -3, respectively.
  • 产品描述
    A potent, orally available, pan-VEGFR inhibitor with IC50 of 10, 30, and 47 nM for VEGFR-1, -2, and -3, respectively; also shows significant activity against the closely related RTKs PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50 of 84, 74, 140, and 146 nM, respectively; potently inhibits VEGF-induced phosphorylation of VEGFR-2 in HUVEC cells with IC50 of 8 nM; inhibits in vivo tumor growth, increases MM cell apoptosis, decreases angiogenesis, and prolongs host survival in a xenograft model of human MM. Kidney Cancer Approved
  • 同义词
    GW-786034B;GW-786034;GW786034
  • 通路
    Angiogenesis
  • 靶点
    VEGFR
  • 受体
    c-Kit;PDGFR;VEGFR1;VEGFR2;VEGFR3
  • 研究领域
    Cancer
  • 适应症
    Kidney Cancer

化学信息

  • CAS Number
    444731-52-6
  • 分子量
    437.52
  • 分子式
    C21H23N7O2S
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO: ≥ 43 mg/mL
  • SMILES
    O=S(C1=CC(NC2=NC=CC(N(C3=CC4=NN(C)C(C)=C4C=C3)C)=N2)=CC=C1C)(N)=O
  • 化学全称
    Benzenesulfonamide, 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Podar K, et al. Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19478-83.
2. Kumar R, et al. Mol Cancer Ther. 2007 Jul;6(7):2012-21.
3. Harris PA, et al. J Med Chem. 2008 Aug 14;51(15):4632-40.
4. Hurwitz HI, et al. Clin Cancer Res. 2009 Jun 15;15(12):4220-7.
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