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Tilfrinib
CAS No. 1600515-49-8
Tilfrinib ( —— )
产品货号. M26845 CAS No. 1600515-49-8
Tilfrinib 是一种有效的选择性乳腺肿瘤激酶抑制剂 (IC50: 3.15 nM)，具有抗增殖活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥437 | 有现货 |
|
| 5MG | ￥721 | 有现货 |
|
| 10MG | ￥1126 | 有现货 |
|
| 25MG | ￥2179 | 有现货 |
|
| 50MG | ￥3953 | 有现货 |
|
| 100MG | ￥5800 | 有现货 |
|
| 500MG | ￥11988 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Tilfrinib
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Tilfrinib 是一种有效的选择性乳腺肿瘤激酶抑制剂 (IC50: 3.15 nM)，具有抗增殖活性。
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产品描述Tilfrinib is an effective and selective inhibitor of breast tumor kinase (IC50: 3.15 nM), which displays anti-proliferative activity.(In Vitro):Tilfrinib is against MCF7, HS-578/T, and BT-549 cells with GI50 values of 0.99, 1.02 and 1.58 μM.
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体外实验Tilfrinib (20 μM; 36 h) shows inhibition of PTK6, and decreases the ETV4 WT-induced expression of CXCL1 or CXCL8 in UM-UC-3 cells and expression of VEGFA or MMP9 in TANs.Tilfrinib (compound 4f) shows good anti-proliferative activity against MCF7, HS-578/T and BT-549 cells with GI50 values of 0.99, 1.02 and 1.58 μM. Western Blot Analysis Cell Line:UM-UC-3 cells (stably expressing FLAG-ETV4 WT or Y392F)Concentration:20 μM Incubation Time:36 h Result:Reduced ETV4 WT-induced expression of CXCL1 or CXCL8 in UM-UC-3 cells and expression of VEGFA or MMP9 in TANs by inhibiting PTK6.
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体内实验——
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同义词——
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通路Tyrosine Kinase
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靶点BTK
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受体Nav1.7 channel
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研究领域——
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适应症——
化学信息
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CAS Number1600515-49-8
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分子量275.311
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分子式C17H13N3O
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 125 mg/mL (454.05 mM)
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SMILESOc1cccc(Nc2ccnc3[nH]c4ccccc4c23)c1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Shinozuka T, et al. Discovery of DS-1971a, a Potent, Selective NaV1.7 Inhibitor [published online ahead of print, 2020 May 26]. J Med Chem. 2020;10.1021/acs.jmedchem.0c00259.
