Thiodigalactoside

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Thiodigalactoside (TDG) 是一种具有口服活性的，有效的半乳凝素 (GAL) 抑制剂，对于 GAL-1 和 GAL-3 的 Kd 值分别为 24 μM，49 μM。Thiodigalactoside 是一种不可代谢的二糖，具有抗炎和抗癌性。Thiodigalactoside 可显着降低饮食诱发的肥胖大鼠的体重增加。

Thiodigalactoside (TDG) is an orally active and potent galectin (GAL) inhibitor with Kd values of 24 μM, 49 μM for GAL1 and GAL3, respectively. Thiodigalactoside, a non-metabolizable disaccharide, has anti-inflammatory and anti-cancer activity. Thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats.

Thiodigalactoside (TDG; 250 and 500?μM) exhibits dose-dependent reduction of fat accumulation based on triglyceride (TG) content and Oil Red O (ORO) staining.

Thiodigalactoside (TDG; 5?mg/kg; IP; once per week for 5 weeks) results in dramatic inhibition of HFD-induced body weight gain. Thiodigalactoside (5?mg/kg; oral; daily or weekly for 5 weeks) gave less reduction in body weight gain compare with i.p.. Animal Model:Five-week-old Sprague-Dawley (SD) male rats Dosage:5?mg/kg Administration:IP; once per week for 5 weeks Result:Resulted in dramatic inhibition of HFD-induced body weight gain by inhibiting adipogenesis and lipogensis as well as by increasing expression of the proteins associated with thermogenesis and energy expenditure.

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Cytoskeleton/Cell Adhesion Molecules

Galectin

Galectin

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51555-87-4

358.36

C12H22O10S

>98% (HPLC)

In Vitro:?H2O 中的溶解度 : 100 mg/mL (279.05 mM; 超声助溶)

OC[C@H]1O[C@@H](S[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@H]1O

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(-20℃)

With Ice Pack

≥ 2 years