LLS30 ( LLS-30 )

产品货号. M13409 CAS No. 2138367-58-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

LLS30
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

LLS30 is a potent, allosteric Galectin-1 (Gal-1) inhibitor.
产品描述

LLS30 is a potent, allosteric Galectin-1 (Gal-1) inhibitor, inhibits AR negative cells PC3, DU145, and AR positive cells, 22RV1 and CWR-R1 cells with IC50 of 10.4 μM, 5.3 μM, 3.3 μM and 5.9 μM, respectively; decreases Gal-1 binding affinity to its binding partners; showes in vivo efficacy in both AR positive and AR negative xenograft models; not only can potentiate the anti-tumor effect of docetaxel to cause complete regression of tumors, but also effectively inhibit the invasion and metastasis of PCa cells in vivo.
同义词

LLS-30
通路

Cytoskeleton/Cell Adhesion Molecules
靶点

Galectin
受体

Galectin
研究领域

——
适应症

——

CAS Number

2138367-58-3
分子量

701.47
分子式

C34H33Cl4N5O3
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C(N)CC(C1=CC=C2N(CC3=CC=C(Cl)C(Cl)=C3)C(C4=CC=C(N(CCO)CCO)C=C4)=NC2=C1)NCC5=CC=C(Cl)C(Cl)=C5
化学全称

3-(2-(4-(bis(2-hydroxyethyl)amino)phenyl)-1-(3,4-dichlorobenzyl)-1H-benzo[d]imidazol-5-yl)-3-((3,4-dichlorobenzyl)amino)propanamide

1. Shih TC, et al. Clin Cancer Res. 2018 Apr 17. pii: clincanres.0157.2018.

计算器

产品手册

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OTX008 (Calixarene 0118, PTX-008) is a calixarene derivative designed to bind the Galectin-1 (Gal1) amphipathic β-sheet conformation.
LLS30

LLS30 is a potent, allosteric Galectin-1 (Gal-1) inhibitor.