Thimerosal ( Thiomersalate;Mercurothiolate )

产品货号. M19490 CAS No. 54-64-8

COA

Datasheet

HNMR

HPLC

MSDS

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产品名称

Thimerosal
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Thimerosal is an organomercurial compound and derivative of thiosalicyclic acid with antibacterial and antifungal properties.
产品描述

Thimerosal is an organomercurial compound and derivative of thiosalicyclic acid with antibacterial and antifungal properties. Although the mechanism of action has not been fully elucidated thimerosal inhibits sulfhydryl-containing active site of various enzymes and binds to sulfhydryl compounds such as glutathione cysteine and SH groups of proteins. In addition thimerosal activates the InsP3 calcium channel on endoplasmic reticular membrane thereby triggering the release of calcium from intracellular stores resulting in a calcium-induced calcium-influx of extracellular calcium. Consequently thimerosal may induce or inhibit cellular functions dependent on calcium signaling.
同义词

Thiomersalate;Mercurothiolate
通路

GPCR/G Protein
靶点

Antibacterial
受体

Antibacterial
研究领域

Inflammation/Immunology
适应症

Septic; Fungal Infection

1.Li X et al. Toxicol Sci. 2014 Jun;139(2):452-65.

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